Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 434939..435534 Replicon chromosome
Accession NZ_CP063518
Organism Escherichia coli strain EH01-18-02

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag IQS16_RS02010 Protein ID WP_000239579.1
Coordinates 435184..435534 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag IQS16_RS02005 Protein ID WP_001223208.1
Coordinates 434939..435190 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS16_RS01995 430604..434383 + 3780 WP_000060895.1 autotransporter assembly complex protein TamB -
IQS16_RS02000 434386..434727 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IQS16_RS02005 434939..435190 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IQS16_RS02010 435184..435534 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
IQS16_RS02015 435614..436144 - 531 WP_000055072.1 inorganic diphosphatase -
IQS16_RS02020 436454..437410 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IQS16_RS02025 437720..439222 + 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
IQS16_RS02030 439233..440257 + 1025 Protein_384 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T178651 WP_000239579.1 NZ_CP063518:435184-435534 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T178651 NZ_CP084206:c70738-70589 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT178651 WP_001223208.1 NZ_CP063518:434939-435190 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT178651 NZ_CP084206:70783-70842 [Escherichia coli]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References