Detailed information of TA system TA178627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3741440..3742260
• Replicon: chromosome
• Accession: NZ_CP063515
• Organism: Escherichia coli strain EH01-18-04-A

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: IQS17_RS18155
• Protein ID: WP_001054379.1
• Coordinates: 3742003..3742260 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: IQS17_RS18150
• Protein ID: WP_000123957.1
• Coordinates: 3741440..3741991 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS17_RS18120	3737134..3738447	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
IQS17_RS18125	3738459..3738737	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IQS17_RS18130	3738734..3739855	-	1122	WP_000010833.1	M42 family metallopeptidase	-
IQS17_RS18135	3740100..3740216	-	117	Protein_3541	VOC family protein	-
IQS17_RS18140	3740254..3740514	-	261	WP_000077645.1	hypothetical protein	-
IQS17_RS18145	3740642..3741388	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
IQS17_RS18150	3741440..3741991	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
IQS17_RS18155	3742003..3742260	-	258	WP_001054379.1	YjhX family toxin	Toxin
IQS17_RS18160	3742637..3742936	-	300	WP_001332034.1	GNAT family N-acetyltransferase	-
IQS17_RS18165	3743014..3743745	+	732	Protein_3547	DNA helicase	-
IQS17_RS18170	3743775..3745388	-	1614	WP_000080195.1	IS66-like element ISEc23 family transposase	-
IQS17_RS18175	3745418..3745768	-	351	WP_000624722.1	IS66 family insertion sequence element accessory protein TnpB	-
IQS17_RS18180	3745765..3746190	-	426	WP_000422741.1	IS66 family insertion sequence hypothetical protein	-
IQS17_RS18185	3746276..3746779	+	504	Protein_3551	DNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T178627 WP_001054379.1 NZ_CP063515:c3742260-3742003 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T178627 NZ_CP084205:651314-651628 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT178627 WP_000123957.1 NZ_CP063515:c3741991-3741440 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT178627 NZ_CP084205:651625-652041 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: B6I030