Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1943411..1944065 Replicon chromosome
Accession NZ_CP063515
Organism Escherichia coli strain EH01-18-04-A

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag IQS17_RS09560 Protein ID WP_000244765.1
Coordinates 1943411..1943818 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag IQS17_RS09565 Protein ID WP_000354050.1
Coordinates 1943799..1944065 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS17_RS09540 1939368..1941101 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
IQS17_RS09545 1941107..1941817 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IQS17_RS09550 1941842..1942738 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IQS17_RS09555 1942850..1943371 + 522 WP_001055874.1 flavodoxin FldB -
IQS17_RS09560 1943411..1943818 - 408 WP_000244765.1 protein YgfX Toxin
IQS17_RS09565 1943799..1944065 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
IQS17_RS09570 1944308..1945288 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
IQS17_RS09575 1945365..1946024 - 660 WP_000250275.1 hemolysin III family protein -
IQS17_RS09580 1946188..1946499 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
IQS17_RS09585 1946544..1947977 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T178615 WP_000244765.1 NZ_CP063515:c1943818-1943411 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T178615 NZ_CP084197:2907173-2907484 [Pantoea agglomerans]
ATGTTATTCATTGAGACTCCTGTATTCACGGAAGATGTAAAGGAACTACTCAGCGATGATGAATATCGCGAGTTTCAACA
ATTCATGGCTGACAATCCAGGCTGGGGTGATGTTATCCAGAATACGGGTGGCCTGCGTAAAGTTCGCTGGGCGGCCAAAG
GCAAAGGTAAGCGTGGCGGCGTTCGGGTGATTTACTATTACAAAGTCTCTGAATCACAAATCAGGCTGTTGCTGATTTAT
AAAAAAGGCGTCCAGGATGATTTATCCGAGGATGAAAAACATCTGTTAAGGGCGTTGAACGAGGGCTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT178615 WP_000354050.1 NZ_CP063515:c1944065-1943799 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178615 NZ_CP084197:2907484-2907777 [Pantoea agglomerans]
ATGGACAAAAAACTGTTTGAGCGTTTGAAAGAAAGCATGACTCAGATGAATGAGATCGTCGAAGGCTCCCGAGCACCTGC
CCGCGAAAGCACAGTCACTGCGGTTAAAGTCAAAGCTATCAGAAACGCTACTGGTCTTTCGCAAAGCGGGTTCGCTAAGC
TGATTTCCGTGAATGTAGACACGCTAAAAAACTGGGAGCAGGGACGACGTGAGCCAACCGGCCCGGCTAAAGCTTTACTC
CGGGCCATAGAACGCGATCCGCAGCATGTGATCCCAGCGCTTGCTGATAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References