Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 18559..19081 Replicon plasmid pEH09-18-41_6
Accession NZ_CP063509
Organism Escherichia coli strain EH09-18-41

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag IQS19_RS24705 Protein ID WP_000220561.1
Coordinates 18559..18840 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag IQS19_RS24710 Protein ID WP_000121743.1
Coordinates 18830..19081 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS19_RS24655 14541..15086 - 546 WP_000757692.1 hypothetical protein -
IQS19_RS24660 15081..15155 - 75 Protein_17 DNA distortion polypeptide 3 -
IQS19_RS24665 15412..15684 - 273 WP_000167280.1 hypothetical protein -
IQS19_RS24670 15701..15847 - 147 WP_001567307.1 hypothetical protein -
IQS19_RS24675 15917..16096 - 180 WP_000439079.1 hypothetical protein -
IQS19_RS24680 16139..16468 - 330 WP_000866654.1 hypothetical protein -
IQS19_RS24685 16562..16804 - 243 WP_000008708.1 hypothetical protein -
IQS19_RS24690 16794..17006 - 213 WP_001446884.1 hypothetical protein -
IQS19_RS24695 17072..17620 - 549 WP_001178641.1 hypothetical protein -
IQS19_RS24700 17694..18209 - 516 WP_001025387.1 J domain-containing protein -
IQS19_RS24705 18559..18840 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS19_RS24710 18830..19081 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
IQS19_RS24715 20146..21015 + 870 WP_001212191.1 replication initiation protein -
IQS19_RS24720 21020..21871 + 852 WP_000435059.1 replication initiation protein -
IQS19_RS24725 21875..22321 + 447 WP_001074378.1 hypothetical protein -
IQS19_RS24730 22389..22811 + 423 WP_000202950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkF / mrkD / mrkC / mrkB / mrkA 1..48901 48901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T178573 WP_000220561.1 NZ_CP063509:c18840-18559 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T178573 NZ_CP084107:c2434126-2433860 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT178573 WP_000121743.1 NZ_CP063509:c19081-18830 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT178573 NZ_CP084107:c2434377-2434126 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCTAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References