Detailed information of TA system TA178569

Bioinformatically predicted

Overview

TA module

• Type: III
• Classification (family/domain): toxIN/ToxN(toxin)
• Location: 2851..3583
• Replicon: plasmid pEH09-18-41_4
• Accession: NZ_CP063507
• Organism: Escherichia coli strain EH09-18-41

Toxin (Protein)

• Gene name: toxN
• Uniprot ID: -
• Locus tag: IQS19_RS24525
• Protein ID: WP_094198730.1
• Coordinates: 2851..3366 (-)
• Length: 172 a.a.

Antitoxin (RNA)

Gene name	toxI
Locus tag	-
Coordinates	3368..3583 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS19_RS24505	390..623	+	234	WP_029401705.1	MbeD family mobilization/exclusion protein	-
IQS19_RS24510	936..1217	-	282	WP_024177387.1	hypothetical protein	-
IQS19_RS24515	1227..1484	-	258	WP_001508827.1	hypothetical protein	-
IQS19_RS24520	2029..2739	+	711	WP_024177388.1	hypothetical protein	-
IQS19_RS24525	2851..3366	-	516	WP_094198730.1	type III toxin-antitoxin system ToxN/AbiQ family toxin	Toxin
-	3368..3583	-	216	NuclAT_0	-	Antitoxin
-	3368..3583	-	216	NuclAT_0	-	Antitoxin
-	3368..3583	-	216	NuclAT_0	-	Antitoxin
-	3368..3583	-	216	NuclAT_0	-	Antitoxin
-	3418..3475	-	58	NuclAT_7	-	-
-	3418..3475	-	58	NuclAT_7	-	-
-	3418..3475	-	58	NuclAT_7	-	-
-	3418..3475	-	58	NuclAT_7	-	-
-	3418..3511	-	94	NuclAT_5	-	-
-	3418..3511	-	94	NuclAT_5	-	-
-	3418..3511	-	94	NuclAT_5	-	-
-	3418..3511	-	94	NuclAT_5	-	-
-	3418..3547	-	130	NuclAT_3	-	-
-	3418..3547	-	130	NuclAT_3	-	-
-	3418..3547	-	130	NuclAT_3	-	-
-	3418..3547	-	130	NuclAT_3	-	-
-	3418..3584	-	167	NuclAT_1	-	-
-	3418..3584	-	167	NuclAT_1	-	-
-	3418..3584	-	167	NuclAT_1	-	-
-	3418..3584	-	167	NuclAT_1	-	-
-	3454..3587	-	134	NuclAT_2	-	-
-	3454..3587	-	134	NuclAT_2	-	-
-	3454..3587	-	134	NuclAT_2	-	-
-	3454..3587	-	134	NuclAT_2	-	-
-	3490..3587	-	98	NuclAT_4	-	-
-	3490..3587	-	98	NuclAT_4	-	-
-	3490..3587	-	98	NuclAT_4	-	-
-	3490..3587	-	98	NuclAT_4	-	-
-	3526..3587	-	62	NuclAT_6	-	-
-	3526..3587	-	62	NuclAT_6	-	-
-	3526..3587	-	62	NuclAT_6	-	-
-	3526..3587	-	62	NuclAT_6	-	-
IQS19_RS24530	4651..4842	-	192	WP_000165987.1	Rop family plasmid primer RNA-binding protein	-
IQS19_RS24535	4907..5230	+	324	WP_001749507.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..6044	6044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ToxN/AbiQ toxin (1-160)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19862.85 Da
• Isoelectric Point: 6.1125

>T178569 WP_094198730.1 NZ_CP063507:c3366-2851 [Escherichia coli]
MKFYTISSSYIKYLKDFDDKVPNSEDPTYNNPKAFIGIVLEIEGHKYLAPLTSPKAWHANVKESSPAFFKLHENGVPDNQ
LGLINLKFMIPIIEAEVSLLDLDSMPDTPYKRMLYKQLQFIRVNEDKISEKSKLLRNLALQGRMQRTCDFAVLEEKYQHF
GKKPEDMEIDD

Nucleotide

• Length: 516 bp

>T178569 NZ_CP084107:c1924584-1924432 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Nucleotide

• Length: 216 bp

>AT178569 NZ_CP063507:c3583-3368 [Escherichia coli]
AGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATT
TGCTACCTTTAAGTGCAGCTAGAAATTCAGGTGATTTGCTACCTTTAAGTGCAGCTAGAAATTTAGGTCATTTACTACCT
TAAAGTAATAAAGTAAAAAAGGCGACTATACACAGTCGCCTTTTTTACGAGAAAAA

Structures

Antitoxin