Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 51190..51791 Replicon plasmid pEH09-18-41_2
Accession NZ_CP063505
Organism Escherichia coli strain EH09-18-41

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag IQS19_RS23515 Protein ID WP_001216045.1
Coordinates 51411..51791 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IQS19_RS23510 Protein ID WP_001190712.1
Coordinates 51190..51411 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS19_RS23480 46932..47438 + 507 WP_015974272.1 Pap -
IQS19_RS23485 47633..48328 + 696 Protein_52 hypothetical protein -
IQS19_RS23490 48699..49061 + 363 WP_001261544.1 hypothetical protein -
IQS19_RS23495 49724..49975 + 252 WP_001667237.1 DNA polymerase III subunit theta -
IQS19_RS23500 49982..50554 - 573 WP_058664396.1 hypothetical protein -
IQS19_RS23505 50728..51117 + 390 WP_000506730.1 DNA repair protein -
IQS19_RS23510 51190..51411 + 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS19_RS23515 51411..51791 + 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IQS19_RS23520 51796..51975 + 180 WP_000113019.1 hypothetical protein -
IQS19_RS23525 52003..53046 + 1044 WP_023356283.1 DUF968 domain-containing protein -
IQS19_RS23530 53135..53587 + 453 WP_001326849.1 late promoter-activating protein -
IQS19_RS23535 53673..54866 + 1194 WP_000219625.1 hypothetical protein -
IQS19_RS23540 54866..56350 + 1485 WP_000124150.1 terminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94185 94185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T178559 WP_001216045.1 NZ_CP063505:51411-51791 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T178559 NZ_CP084103:c4584591-4584307 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT178559 WP_001190712.1 NZ_CP063505:51190-51411 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT178559 NZ_CP084103:c4584823-4584581 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References