Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4126855..4127641 Replicon chromosome
Accession NZ_CP063503
Organism Escherichia coli strain EH09-18-41

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag IQS19_RS19845 Protein ID WP_016154457.1
Coordinates 4127264..4127641 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A242VSK1
Locus tag IQS19_RS19840 Protein ID WP_009652436.1
Coordinates 4126855..4127214 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS19_RS19780 4121946..4122212 + 267 WP_009652486.1 hypothetical protein -
IQS19_RS19785 4122225..4122536 + 312 WP_009652410.1 hypothetical protein -
IQS19_RS19790 4122583..4123053 + 471 WP_009652431.1 hypothetical protein -
IQS19_RS19795 4123102..4123614 + 513 WP_009652395.1 DUF4234 domain-containing protein -
IQS19_RS19800 4123697..4123918 + 222 WP_009652443.1 hypothetical protein -
IQS19_RS19805 4123974..4124207 + 234 WP_009652474.1 DUF905 domain-containing protein -
IQS19_RS19810 4124311..4125129 + 819 WP_009652424.1 DUF945 domain-containing protein -
IQS19_RS19815 4125129..4125383 + 255 WP_009652519.1 hypothetical protein -
IQS19_RS19820 4125412..4125873 + 462 WP_045890390.1 antirestriction protein -
IQS19_RS19825 4125884..4126102 + 219 WP_009652503.1 hypothetical protein -
IQS19_RS19830 4126114..4126596 + 483 WP_016154455.1 DNA repair protein RadC -
IQS19_RS19835 4126610..4126831 + 222 WP_009652392.1 DUF987 domain-containing protein -
IQS19_RS19840 4126855..4127214 + 360 WP_009652436.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS19_RS19845 4127264..4127641 + 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
IQS19_RS19850 4127638..4128129 + 492 WP_009652438.1 hypothetical protein -
IQS19_RS19855 4128159..4128362 + 204 WP_009652505.1 DUF957 domain-containing protein -
IQS19_RS19860 4128443..4129288 + 846 Protein_3863 DUF4942 domain-containing protein -
IQS19_RS19865 4129300..4129539 + 240 WP_203152187.1 hypothetical protein -
IQS19_RS19870 4129677..4130213 - 537 WP_024238456.1 GspM family type II secretion system protein YghD -
IQS19_RS19875 4130215..4131393 - 1179 WP_024238457.1 type II secretion system protein GspL -
IQS19_RS19880 4131390..4132367 - 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T178555 WP_016154457.1 NZ_CP063503:4127264-4127641 [Escherichia coli]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T178555 NZ_CP084103:c2570933-2569611 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTAACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAACGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCTGGCGCTATAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13286.19 Da        Isoelectric Point: 6.4780

>AT178555 WP_009652436.1 NZ_CP063503:4126855-4127214 [Escherichia coli]
MSNTIPPVNHDIAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELN
PRHQHCVTLYAKGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 360 bp

>AT178555 NZ_CP084103:c2571199-2570933 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN26

Antitoxin

Source ID Structure
AlphaFold DB A0A242VSK1

References