Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3034113..3034948 Replicon chromosome
Accession NZ_CP063503
Organism Escherichia coli strain EH09-18-41

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag IQS19_RS14735 Protein ID WP_000854752.1
Coordinates 3034571..3034948 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag IQS19_RS14730 Protein ID WP_001278232.1
Coordinates 3034113..3034481 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS19_RS14700 3030949..3031404 + 456 WP_000581504.1 hypothetical protein -
IQS19_RS14705 3031483..3031716 + 234 WP_001119729.1 DUF905 family protein -
IQS19_RS14710 3031816..3032634 + 819 WP_001234620.1 DUF945 domain-containing protein -
IQS19_RS14715 3032689..3033174 + 486 WP_000849582.1 antirestriction protein -
IQS19_RS14720 3033190..3033666 + 477 WP_001186774.1 RadC family protein -
IQS19_RS14725 3033729..3033950 + 222 WP_000692318.1 DUF987 domain-containing protein -
IQS19_RS14730 3034113..3034481 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IQS19_RS14735 3034571..3034948 + 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
IQS19_RS14740 3034945..3035148 + 204 WP_000761705.1 hypothetical protein -
IQS19_RS14745 3035161..3035274 + 114 WP_001161660.1 DUF957 domain-containing protein -
IQS19_RS14750 3036090..3036461 + 372 WP_001295631.1 IS110 family transposase -
IQS19_RS14755 3036620..3037093 - 474 Protein_2867 IS3 family transposase -
IQS19_RS14760 3037183..3038691 - 1509 WP_001474883.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T178551 WP_000854752.1 NZ_CP063503:3034571-3034948 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T178551 NZ_CP084097:128453-128851 [Escherichia coli O78]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT178551 WP_001278232.1 NZ_CP063503:3034113-3034481 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT178551 NZ_CP084097:128226-128453 [Escherichia coli O78]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References