Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 12478..13013 Replicon plasmid pEH10-18-47_3
Accession NZ_CP063502
Organism Escherichia coli strain EH10-18-47

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag IQS20_RS22490 Protein ID WP_000222771.1
Coordinates 12478..12765 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag IQS20_RS22495 Protein ID WP_001139206.1
Coordinates 12762..13013 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS20_RS22475 8085..11618 + 3534 WP_094317721.1 autotransporter outer membrane beta-barrel domain-containing protein -
IQS20_RS22480 11793..11998 - 206 Protein_11 transposase -
IQS20_RS22485 11988..12188 + 201 WP_032214362.1 DUF839 domain-containing protein -
IQS20_RS22490 12478..12765 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS20_RS22495 12762..13013 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS20_RS22500 13626..13865 + 240 Protein_15 hypothetical protein -
IQS20_RS22505 14094..15494 + 1401 WP_032185977.1 cytochrome ubiquinol oxidase subunit I -
IQS20_RS22510 15494..16504 + 1011 WP_000510495.1 cytochrome d ubiquinol oxidase subunit II -
IQS20_RS22515 16504..16632 + 129 WP_001164804.1 DUF2474 domain-containing protein -
IQS20_RS22520 16737..17150 - 414 Protein_19 collagenase-like protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / tet(A) / floR / qnrS1 - 1..89721 89721


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T178534 WP_000222771.1 NZ_CP063502:c12765-12478 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T178534 NZ_CP084096:2921257-2921433 [Escherichia coli O78]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGATGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT178534 WP_001139206.1 NZ_CP063502:c13013-12762 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT178534 NZ_CP084096:2921479-2921895 [Escherichia coli O78]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References