178510

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 6949..7442 Replicon plasmid pEF5-18-41_4
Accession NZ_CP063496
Organism Escherichia coli strain EF5-18-41

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag IQS14_RS27995 Protein ID WP_001230709.1
Coordinates 6949..7203 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag IQS14_RS28000 Protein ID WP_000151456.1
Coordinates 7200..7442 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS14_RS27960 2522..2683 + 162 WP_001366886.1 type I toxin-antitoxin system Hok family toxin -
IQS14_RS27965 2833..3429 + 597 WP_000125165.1 hypothetical protein -
IQS14_RS27970 3447..3731 - 285 WP_001162371.1 hypothetical protein -
IQS14_RS27975 3805..4470 - 666 WP_203154783.1 P-loop NTPase -
IQS14_RS27980 5058..5387 + 330 WP_000855119.1 hypothetical protein -
IQS14_RS27985 5791..6306 + 516 WP_001025393.1 J domain-containing protein -
IQS14_RS27990 6410..6952 + 543 WP_001083904.1 hypothetical protein -
IQS14_RS27995 6949..7203 + 255 WP_001230709.1 hypothetical protein Toxin
IQS14_RS28000 7200..7442 + 243 WP_000151456.1 hypothetical protein Antitoxin
IQS14_RS28005 8013..8294 + 282 WP_021563355.1 hypothetical protein -
IQS14_RS28010 8304..8720 + 417 WP_097728064.1 phage tail protein -
IQS14_RS28015 8717..9028 + 312 WP_000627398.1 hypothetical protein -
IQS14_RS28020 9514..9762 + 249 WP_106509039.1 type II toxin-antitoxin system HicA family toxin -
IQS14_RS28025 9759..10106 + 348 WP_000681609.1 type II toxin-antitoxin system HicB family antitoxin -
IQS14_RS28030 10194..10376 - 183 WP_001428470.1 hypothetical protein -
IQS14_RS28035 10934..11116 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
IQS14_RS28040 11141..11578 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
IQS14_RS28045 11709..12029 - 321 WP_001401701.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..63909 63909
- flank IS/Tn - - 1050..2198 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T178510 WP_001230709.1 NZ_CP063496:6949-7203 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T178510 NZ_CP084055:c2670273-2670166 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT178510 WP_000151456.1 NZ_CP063496:7200-7442 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT178510 NZ_CP084055:2670321-2670387 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References