178507

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 19965..20500 Replicon plasmid pEF5-18-41_2
Accession NZ_CP063494
Organism Escherichia coli strain EF5-18-41

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8WEY8
Locus tag IQS14_RS26830 Protein ID WP_032353555.1
Coordinates 19965..20252 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WHE0
Locus tag IQS14_RS26835 Protein ID WP_045145550.1
Coordinates 20249..20500 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS14_RS26810 15146..16333 + 1188 WP_045145541.1 IS91 family transposase -
IQS14_RS26815 17187..17780 + 594 WP_032353553.1 proQ/FINO family protein -
IQS14_RS26820 18060..18647 - 588 WP_064550130.1 colanic acid biosynthesis acetyltransferase -
IQS14_RS26825 19668..19955 - 288 WP_045145547.1 hypothetical protein -
IQS14_RS26830 19965..20252 - 288 WP_032353555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS14_RS26835 20249..20500 - 252 WP_045145550.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS14_RS26840 20587..20754 - 168 WP_045145553.1 hypothetical protein -
IQS14_RS26845 21449..22321 - 873 WP_045145554.1 incFII family plasmid replication initiator RepA -
IQS14_RS26850 23022..23663 + 642 WP_021547665.1 hypothetical protein -
IQS14_RS26855 23804..24469 + 666 WP_065203167.1 traC -
IQS14_RS26860 24736..25356 + 621 WP_072648954.1 DUF1449 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..150711 150711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.16 Da        Isoelectric Point: 10.6261

>T178507 WP_032353555.1 NZ_CP063494:c20252-19965 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T178507 NZ_CP084055:c2052778-2052371 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9219.48 Da        Isoelectric Point: 4.1789

>AT178507 WP_045145550.1 NZ_CP063494:c20500-20249 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHYVDLD
SYL

Download         Length: 252 bp

>AT178507 NZ_CP084055:c2053025-2052759 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WHE0

References