Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5126941..5127782 Replicon chromosome
Accession NZ_CP063492
Organism Escherichia coli strain EF5-18-41

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag IQS14_RS24930 Protein ID WP_000854822.1
Coordinates 5126941..5127324 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MK11
Locus tag IQS14_RS24935 Protein ID WP_001285610.1
Coordinates 5127414..5127782 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS14_RS24900 5122586..5124427 + 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -
IQS14_RS24905 5124506..5125012 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
IQS14_RS24915 5125311..5126156 - 846 WP_001280435.1 DUF4942 domain-containing protein -
IQS14_RS24920 5126253..5126450 - 198 WP_000839263.1 DUF957 domain-containing protein -
IQS14_RS24925 5126462..5126950 - 489 WP_001177592.1 hypothetical protein -
IQS14_RS24930 5126941..5127324 - 384 WP_000854822.1 type IV toxin-antitoxin system toxin CbtA Toxin
IQS14_RS24935 5127414..5127782 - 369 WP_001285610.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS14_RS24940 5127862..5128083 - 222 WP_000692350.1 DUF987 domain-containing protein -
IQS14_RS24945 5128152..5128628 - 477 WP_072661507.1 RadC family protein -
IQS14_RS24950 5128644..5129129 - 486 WP_072794436.1 antirestriction protein -
IQS14_RS24955 5129220..5130038 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T178501 WP_000854822.1 NZ_CP063492:c5127324-5126941 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T178501 NZ_CP084055:c323388-323281 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13606.39 Da        Isoelectric Point: 6.0618

>AT178501 WP_001285610.1 NZ_CP063492:c5127782-5127414 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT178501 NZ_CP084055:323435-323501 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure

References