Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1984428..1985046 Replicon chromosome
Accession NZ_CP063492
Organism Escherichia coli strain EF5-18-41

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag IQS14_RS09390 Protein ID WP_001291435.1
Coordinates 1984428..1984646 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag IQS14_RS09395 Protein ID WP_000344800.1
Coordinates 1984672..1985046 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS14_RS09355 1979717..1980289 + 573 WP_000779826.1 lipoprotein -
IQS14_RS09360 1980320..1980631 - 312 WP_000409911.1 MGMT family protein -
IQS14_RS09370 1981010..1981363 + 354 WP_000878140.1 DUF1428 domain-containing protein -
IQS14_RS09375 1981405..1982955 - 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
IQS14_RS09380 1983119..1983589 - 471 WP_000136192.1 YlaC family protein -
IQS14_RS09385 1983705..1984256 - 552 WP_000102559.1 maltose O-acetyltransferase -
IQS14_RS09390 1984428..1984646 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
IQS14_RS09395 1984672..1985046 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
IQS14_RS09400 1985592..1988741 - 3150 WP_001132480.1 multidrug efflux RND transporter permease subunit -
IQS14_RS09405 1988764..1989957 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T178479 WP_001291435.1 NZ_CP063492:c1984646-1984428 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T178479 NZ_CP084032:c608125-607196 [Pectobacterium colocasium]
ATAGATCAGCGTGATATTTATGCCCGACAGGTCAAGCTGTTAATGACCTCCCTGCCGTATGTGGCGAAAGAACCCTGCTT
CGCGCTGAAAGGCGGCACAGCAATTAATTTATTTGTGCAGGATTTTCCTCGTCTATCGGTAGATATCGATCTGGTTTATC
AAACCTTCATAGATCGTGATACCGATCTAATCGCTATTGACGATGCATTGATGCGTATTACGGAATCGCTGAACGGCAGG
CCGGGGATCACAGCGATCCGGCAGGAGAATAAAGCCGATGAAAAACGCATCATCGTTAACACCGTTGATGCGCAGATAAA
GATTGAAGTCAGCCCGGTTTGGCGTGGATTGCTGTTACCTCCAGCAGAAATGCCGATATGCGAGCAGGTGGAAATGGAAT
TCGGCTTTACCATCATGAATGTCGTTTCACTGGCAGATCTTTACGGCGGTAAAATCTGCGCCGCGCTCGATCGCCAGCAT
CCACGCGATCTGTTTGATGTGCTAAATATGCTGGAGAAACCGGGCCTCACACGTGAGCTCTTTGATGGCTTTCTTTGTTA
TCTGGCTGGTCATCCCCGTCCCATCGCCGAACTACTGGCACCAAACTGGGACATTGCACGGATCGCTACACTGTACCAAC
AGGAATTTTCGGGTATGGCGCAGCATGAAACGTCGCTGGAATCGCTTTTGTCGGTAACGACTTTACTGCCGCAAGCATTG
AAATCTCATTTTACCGCTCAGGATAAACAGTTTTTACTGGGCTATAAGCAAAACACTCCTGACTGGTCGCTATATCGCTA
TCCTGATATTCAACATCTTCCCGCTATTCGCTGGAAACAGCGTAATTTATCAGCCTTACATGCTAAAAATCCGGCCAAAT
TTAGCGCAGCGGTAGGCAAGCTTGAGAAGGTTCTGGAACAGTGCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT178479 WP_000344800.1 NZ_CP063492:c1985046-1984672 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT178479 NZ_CP084032:c608894-608112 [Pectobacterium colocasium]
TTGACAAATTATCTAAACTGGATGATGCAAAACACGCTGCCCGGTCAGGTGTTGCTCCAATCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTCTCTTACGTCTATGTCCAAAACGGTTGGCTCAGGCGGATCGCGCACGGCGTTTACTGCCGGACGG
GCCGAGAACCGGATTGGGTAGATGCGGTTTATTGCCTGCAAACCCAATGGGAAAAACCTGTACGGGTGGCAGGGCTGACC
AGCCTTGCGCTACAGGGCTATTCCCACTATACCGAACTGGGTAAACCTCAAATCTGGCTCACGCTCCCGGCGTACATTAC
GCTACCGGGGTGGTTCGCCGCCTTTGAAAAATCCGCCACCTTTGTCGTTATCTACACATCAGGCCTGTCGGTTGATGTGA
TGCCATTCACTACAGAACTAAAAATCGGCGATCGGCGGCTGACTGGCAGTGTTCCAGAACTTGCCGCGTATGAAATCGCC
AGCGGCGTTCCCACACAAATATCATTTGAGCATGCCGATGCATTGTTTCAGGGTCTACACCTTCTCAGCCCGCGAAAATT
ACAGGCACTGCTCTGCGCCAGTCATTCAGTAAAAACCAACCGGGTGATGCTCTACCTTGCCCAGCGTAACGGACATCCTT
ATTTTCAGTATCTTGATAAAAGTGGTATAGAAATAGGCGCTGGAAAGCGGCAAATTGTCCCCGGCGGCTGGCTGGAACCG
GATTACCAAATCACCGTTCCCAGGGAATTTAAATCGAAAGGAATCGAAGATAGATCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References