Detailed information of TA system TA178468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 887831..888819
• Replicon: chromosome
• Accession: NZ_CP063492
• Organism: Escherichia coli strain EF5-18-41

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: IQS14_RS04135
• Protein ID: WP_014640052.1
• Coordinates: 888433..888819 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: IQS14_RS04130
• Protein ID: WP_000458583.1
• Coordinates: 887831..888403 (+)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS14_RS04100	882942..883550	+	609	WP_000646078.1	transcriptional repressor LexA	-
IQS14_RS04105	883623..884948	+	1326	WP_001301116.1	MATE family efflux transporter DinF	-
IQS14_RS04110	885064..885273	+	210	WP_001030593.1	CsbD family protein	-
IQS14_RS04115	885315..885830	-	516	WP_000416263.1	zinc uptake transcriptional repressor Zur	-
IQS14_RS04120	886148..887110	+	963	WP_000912582.1	DUF2713 family protein	-
IQS14_RS04125	887473..887595	+	123	WP_001300034.1	hypothetical protein	-
IQS14_RS04130	887831..888403	+	573	WP_000458583.1	SocA family protein	Antitoxin
IQS14_RS04135	888433..888819	+	387	WP_014640052.1	hypothetical protein	Toxin
IQS14_RS04140	888859..889032	+	174	WP_000390072.1	hypothetical protein	-
IQS14_RS04145	889080..889361	-	282	WP_001093916.1	pyocin activator PrtN family protein	-
IQS14_RS04150	889398..890150	-	753	WP_201356665.1	hypothetical protein	-
IQS14_RS04155	890369..891193	-	825	WP_000081311.1	DUF2303 family protein	-
IQS14_RS04160	891259..891621	-	363	WP_000135680.1	hypothetical protein	-
IQS14_RS04165	892308..892982	-	675	WP_000859461.1	LexA family transcriptional regulator	-
IQS14_RS04170	893073..893273	+	201	WP_000649477.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T178468 WP_014640052.1 NZ_CP063492:888433-888819 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T178468 NZ_CP084027:c276485-276042 [Escherichia coli]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT178468 WP_000458583.1 NZ_CP063492:887831-888403 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT178468 NZ_CP084027:c276712-276482 [Escherichia coli]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1