Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 76015..76550 Replicon plasmid pEF7-18-51_1
Accession NZ_CP063488
Organism Escherichia coli strain EF7-18-51

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IQS15_RS22320 Protein ID WP_032206513.1
Coordinates 76015..76302 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag IQS15_RS22325 Protein ID WP_001139206.1
Coordinates 76299..76550 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS15_RS22305 71640..75155 + 3516 WP_089571546.1 autotransporter outer membrane beta-barrel domain-containing protein -
IQS15_RS22310 75330..75535 - 206 Protein_69 transposase -
IQS15_RS22315 75525..75725 + 201 WP_000896262.1 DUF839 domain-containing protein -
IQS15_RS22320 76015..76302 - 288 WP_032206513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS15_RS22325 76299..76550 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS15_RS22330 77161..81099 + 3939 WP_130562332.1 helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(A) / blaTEM-1B / aac(3)-IId / dfrA15 / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / aph(3'')-Ib / aph(6)-Id - 1..172246 172246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11130.20 Da        Isoelectric Point: 10.5833

>T178462 WP_032206513.1 NZ_CP063488:c76302-76015 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQIIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T178462 NZ_CP084026:c3999960-3999853 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT178462 WP_001139206.1 NZ_CP063488:c76550-76299 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT178462 NZ_CP084026:4000009-4000075 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References