Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3014002..3014528 Replicon chromosome
Accession NZ_CP063483
Organism Escherichia coli strain EM03-18-08

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IQS21_RS14505 Protein ID WP_000323025.1
Coordinates 3014241..3014528 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IQS21_RS14500 Protein ID WP_000534858.1
Coordinates 3014002..3014241 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS21_RS14470 3009361..3009708 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
IQS21_RS14475 3009705..3010109 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
IQS21_RS14480 3010331..3010618 + 288 Protein_2812 hypothetical protein -
IQS21_RS14485 3011387..3012700 + 1314 WP_000589005.1 ISNCY family transposase -
IQS21_RS14490 3013137..3013469 - 333 WP_001301033.1 protein FlxA -
IQS21_RS14495 3013672..3013977 - 306 WP_001326990.1 hypothetical protein -
IQS21_RS14500 3014002..3014241 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IQS21_RS14505 3014241..3014528 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IQS21_RS14510 3014600..3014755 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
IQS21_RS14515 3014972..3015223 + 252 WP_000980994.1 hypothetical protein -
IQS21_RS14520 3015290..3015568 + 279 WP_012304870.1 hypothetical protein -
IQS21_RS14525 3015570..3016619 + 1050 WP_001265199.1 DUF968 domain-containing protein -
IQS21_RS14530 3016633..3017124 + 492 WP_052424683.1 antitermination protein -
IQS21_RS14535 3017158..3017855 + 698 WP_106423973.1 IS1 family transposase -
IQS21_RS14540 3018193..3018408 + 216 WP_000839590.1 phage lysis protein EssD -
IQS21_RS14545 3018413..3018724 + 312 WP_000189916.1 YdfR family protein -
IQS21_RS14550 3018721..3019254 + 534 WP_001092971.1 lysozyme -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2998422..3050177 51755
- flank IS/Tn - - 3017562..3017855 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T178428 WP_000323025.1 NZ_CP063483:3014241-3014528 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T178428 NZ_CP084023:177968-178243 [Pectobacterium aroidearum]
ATGCAGGGAAAAATAGCCAGTCTACGAAAAAAGCAGCGAGAAACGCTGAGCCAAATTTTCAAAACACCCGTGCTTTCAGG
TGTTAAATGGTCAAATGTTGAGTCACTCATCACTGCGTTAGGTGGTGAAATTAAGGAAGGTAGCGGGTCACGGGTGCGAT
TTTTATTGAATGGGAGTATCGCCCGGTTCCATCGTCCTCACCCGTCACCGGATACTGATAAAGGCGCATTGGTTAACCTG
CGTGAATGGTTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT178428 WP_000534858.1 NZ_CP063483:3014002-3014241 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT178428 NZ_CP084023:178240-178602 [Pectobacterium aroidearum]
ATGACTAAAGCACTTAACACACCAAATACGATGGTTGTTTCCGGCCAACCGGCCATTATCAGCTATGTACCGGAAATCGG
TATGTTTCGCGGTAAGTTTATTGGCTTATCTGGCTACTGTGATTTTGTCGCTGACAGTATTAATGGGCTGAGAAACGAGG
GCGAAATTTCGCTACGTGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAACGTGAAGAGAAGGTGAAA
ACGTTCACTCTCCGTTATCCTGAATCATTCGGAGAACGACTGACTATTGCGGCGGCTGAGCGTCAAATTTCAGTGAATAC
GTTTATTGTCGAAACGCTTAATGAACGTATGAAACAGGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References