Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2581384..2582215 | Replicon | chromosome |
| Accession | NZ_CP063483 | ||
| Organism | Escherichia coli strain EM03-18-08 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | IQS21_RS12280 | Protein ID | WP_039268420.1 |
| Coordinates | 2581384..2581758 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | F4THW5 |
| Locus tag | IQS21_RS12285 | Protein ID | WP_001313071.1 |
| Coordinates | 2581847..2582215 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IQS21_RS12240 | 2576780..2577946 | + | 1167 | WP_001310935.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| IQS21_RS12245 | 2578065..2578538 | + | 474 | WP_001105393.1 | DNA gyrase inhibitor SbmC | - |
| IQS21_RS12250 | 2578736..2579794 | + | 1059 | WP_001200905.1 | FUSC family protein | - |
| IQS21_RS12255 | 2579966..2580295 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| IQS21_RS12260 | 2580396..2580578 | - | 183 | WP_001016348.1 | hypothetical protein | - |
| IQS21_RS12265 | 2580632..2580778 | + | 147 | Protein_2380 | transposase domain-containing protein | - |
| IQS21_RS12270 | 2581067..2581180 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| IQS21_RS12275 | 2581193..2581387 | - | 195 | WP_000988600.1 | hypothetical protein | - |
| IQS21_RS12280 | 2581384..2581758 | - | 375 | WP_039268420.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| IQS21_RS12285 | 2581847..2582215 | - | 369 | WP_001313071.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| IQS21_RS12290 | 2582295..2582516 | - | 222 | WP_000692301.1 | DUF987 domain-containing protein | - |
| IQS21_RS12295 | 2582579..2583055 | - | 477 | WP_001186726.1 | RadC family protein | - |
| IQS21_RS12300 | 2583071..2583550 | - | 480 | WP_000860076.1 | antirestriction protein | - |
| IQS21_RS12305 | 2583632..2584453 | - | 822 | WP_001234530.1 | DUF945 domain-containing protein | - |
| IQS21_RS12310 | 2584674..2584943 | - | 270 | WP_000995808.1 | hypothetical protein | - |
| IQS21_RS12315 | 2585022..2585720 | - | 699 | Protein_2390 | IS1-like element IS1A family transposase | - |
| IQS21_RS12320 | 2586345..2586890 | + | 546 | WP_000973176.1 | bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2537654..2598464 | 60810 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14000.00 Da Isoelectric Point: 7.1333
>T178419 WP_039268420.1 NZ_CP063483:c2581758-2581384 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINNIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T178419 NZ_CP084012:c1750389-1750054 [Bifidobacterium longum]
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA
ATGCTCAAACCGGATTACACGGCGGCATTCCAGCGAGATATCAAGAAGCTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTACTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTTGGGCAAATAGCGGGTTTACATCCTGCTTTGAACCA
GCCGACGGCGATTTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13498.23 Da Isoelectric Point: 5.8696
>AT178419 WP_001313071.1 NZ_CP063483:c2582215-2581847 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT178419 NZ_CP084012:c1750662-1750393 [Bifidobacterium longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAAGCGCATTCCCCTAAACCTTTCCTATACGA
TCGTGCCGCCTGAAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCAACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|