Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4597034..4597866 Replicon chromosome
Accession NZ_CP063479
Organism Escherichia coli strain EM06-18-14

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag IQS22_RS22060 Protein ID WP_000854753.1
Coordinates 4597492..4597866 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag IQS22_RS22055 Protein ID WP_001278232.1
Coordinates 4597034..4597402 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS22_RS22025 4593870..4594325 + 456 WP_072645706.1 hypothetical protein -
IQS22_RS22030 4594404..4594637 + 234 WP_001119729.1 DUF905 family protein -
IQS22_RS22035 4594737..4595555 + 819 WP_001234620.1 DUF945 domain-containing protein -
IQS22_RS22040 4595610..4596095 + 486 WP_000849582.1 antirestriction protein -
IQS22_RS22045 4596111..4596587 + 477 WP_001186726.1 RadC family protein -
IQS22_RS22050 4596650..4596871 + 222 WP_000692329.1 DUF987 domain-containing protein -
IQS22_RS22055 4597034..4597402 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
IQS22_RS22060 4597492..4597866 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
IQS22_RS22065 4597863..4598351 + 489 WP_000777545.1 hypothetical protein -
IQS22_RS22070 4598363..4598560 + 198 WP_000839281.1 DUF957 domain-containing protein -
IQS22_RS22075 4598657..4599229 + 573 WP_001290246.1 DUF4942 domain-containing protein -
IQS22_RS22080 4599510..4600046 - 537 WP_000942786.1 GspM family type II secretion system protein YghD -
IQS22_RS22085 4600048..4601226 - 1179 WP_000094974.1 type II secretion system protein GspL -
IQS22_RS22090 4601223..4602200 - 978 WP_000633222.1 type II secretion system minor pseudopilin GspK -
IQS22_RS22095 4602203..4602802 - 600 WP_001255040.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T178401 WP_000854753.1 NZ_CP063479:4597492-4597866 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T178401 NZ_CP084001:201051-201536 [Salmonella sp. A7]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACTTTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT178401 WP_001278232.1 NZ_CP063479:4597034-4597402 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT178401 NZ_CP084001:200776-201063 [Salmonella sp. A7]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCTGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References