Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2875676..2876314 Replicon chromosome
Accession NZ_CP063479
Organism Escherichia coli strain EM06-18-14

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag IQS22_RS13830 Protein ID WP_000813794.1
Coordinates 2875676..2875852 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IQS22_RS13835 Protein ID WP_001270285.1
Coordinates 2875898..2876314 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS22_RS13810 2871295..2872509 - 1215 WP_001326689.1 BenE family transporter YdcO -
IQS22_RS13815 2872562..2873098 + 537 WP_000429153.1 DNA-binding transcriptional regulator SutR -
IQS22_RS13820 2873171..2875132 + 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
IQS22_RS13825 2875224..2875454 - 231 WP_000494244.1 YncJ family protein -
IQS22_RS13830 2875676..2875852 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
IQS22_RS13835 2875898..2876314 + 417 WP_001270285.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
IQS22_RS13840 2876393..2877799 + 1407 WP_000760590.1 PLP-dependent aminotransferase family protein -
IQS22_RS13845 2878044..2879189 + 1146 WP_000034363.1 ABC transporter substrate-binding protein -
IQS22_RS13850 2879207..2880220 + 1014 WP_000220411.1 ABC transporter ATP-binding protein -
IQS22_RS13855 2880221..2881162 + 942 WP_001251313.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2870107..2871255 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T178387 WP_000813794.1 NZ_CP063479:2875676-2875852 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T178387 NZ_CP083990:2608728-2608835 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15247.61 Da        Isoelectric Point: 4.6115

>AT178387 WP_001270285.1 NZ_CP063479:2875898-2876314 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFDLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT178387 NZ_CP083990:c2608681-2608615 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References