Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 64217..64752 Replicon plasmid pEM10-18-28_1
Accession NZ_CP063477
Organism Escherichia coli strain EM10-18-28

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag IQS23_RS23905 Protein ID WP_000222771.1
Coordinates 64465..64752 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag IQS23_RS23900 Protein ID WP_001139206.1
Coordinates 64217..64468 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS23_RS23875 59384..60073 - 690 WP_203038317.1 EAL domain-containing protein -
IQS23_RS23880 60308..61029 + 722 Protein_65 helix-turn-helix domain-containing protein -
IQS23_RS23885 61068..61316 - 249 WP_000747846.1 hypothetical protein -
IQS23_RS23890 61313..61753 - 441 WP_023352064.1 hypothetical protein -
IQS23_RS23895 61787..63604 - 1818 Protein_68 helicase -
IQS23_RS23900 64217..64468 + 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS23_RS23905 64465..64752 + 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS23_RS23910 65042..65242 - 201 WP_000896262.1 DUF839 domain-containing protein -
IQS23_RS23915 65232..65437 + 206 Protein_72 transposase -
IQS23_RS23920 65612..69163 - 3552 WP_097307726.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / dfrA14 / blaTEM-1A / floR / tet(A) / aph(6)-Id - 1..113297 113297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T178377 WP_000222771.1 NZ_CP063477:64465-64752 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

>T178377 NZ_CP083990:974677-975012 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT178377 WP_001139206.1 NZ_CP063477:64217-64468 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp

>AT178377 NZ_CP083990:974429-974677 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References