Detailed information of TA system TA178369

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3060731..3061326
• Replicon: chromosome
• Accession: NZ_CP063476
• Organism: Escherichia coli strain EM10-18-28

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: IQS23_RS14800
• Protein ID: WP_063815121.1
• Coordinates: 3060731..3061081 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: IQS23_RS14805
• Protein ID: WP_001223213.1
• Coordinates: 3061075..3061326 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS23_RS14780	3056185..3057207	-	1023	WP_001298067.1	ABC transporter permease	-
IQS23_RS14785	3057221..3058723	-	1503	WP_022646474.1	sugar ABC transporter ATP-binding protein	-
IQS23_RS14790	3058856..3059812	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
IQS23_RS14795	3060122..3060652	+	531	WP_000055075.1	inorganic diphosphatase	-
IQS23_RS14800	3060731..3061081	-	351	WP_063815121.1	endoribonuclease toxin ChpB	Toxin
IQS23_RS14805	3061075..3061326	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
IQS23_RS14810	3061538..3061879	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
IQS23_RS14815	3061882..3065661	-	3780	WP_022646473.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-115)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12443.37 Da
• Isoelectric Point: 6.2206

>T178369 WP_063815121.1 NZ_CP063476:c3061081-3060731 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVASITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T178369 NZ_CP083974:c3068910-3068341 [Rhodococcus rhodochrous]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAATGGTTCCGGTAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGGGCAGCGTGTTCGTCAACGCGGATGTGATCGCGCGGCAACGTTGGCCCGACCGTGCCGAGGAGATGTCGTACGAGG
CGGCGCAACTCGCCGCGTCGGCGCGGGATCGGTTGCTGCGGCAGGGCCGGTCGTTCATCGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGCTGATCGACCGGGCACACGAGGCGGGCTTCACGGTGGTGTTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTGCAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCGGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGGTCGAGGCGATCGGTCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT178369 WP_001223213.1 NZ_CP063476:c3061326-3061075 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT178369 NZ_CP083974:c3069293-3068907 [Rhodococcus rhodochrous]
ATGACGTCGTCCACCGACAAGGTCACCCGCTTCGACGCCGAGCTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGTATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCTTTGCATC
GGGTGCACGAGGCGCTGGCCGGGACGCGGGAGCTGAGTGAGCTCACCGCCGCGGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATCCTTGCTGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAGGGCCGGTTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Structures

Antitoxin

• AlphaFold DB: L4JJX7