Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 684535..685367 Replicon chromosome
Accession NZ_CP063476
Organism Escherichia coli strain EM10-18-28

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1L4HFA4
Locus tag IQS23_RS03210 Protein ID WP_032163901.1
Coordinates 684535..684909 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag IQS23_RS03215 Protein ID WP_001295723.1
Coordinates 684999..685367 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS23_RS03170 679931..681097 + 1167 WP_042031746.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
IQS23_RS03175 681216..681689 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
IQS23_RS03180 681887..682945 + 1059 WP_001200891.1 FUSC family protein -
IQS23_RS03185 683117..683446 + 330 WP_000450409.1 DUF496 family protein -
IQS23_RS03190 683547..683729 - 183 WP_001016348.1 hypothetical protein -
IQS23_RS03195 683801..683929 + 129 Protein_626 transposase domain-containing protein -
IQS23_RS03200 684218..684331 - 114 WP_001161660.1 DUF957 domain-containing protein -
IQS23_RS03205 684344..684538 - 195 WP_000988600.1 hypothetical protein -
IQS23_RS03210 684535..684909 - 375 WP_032163901.1 TA system toxin CbtA family protein Toxin
IQS23_RS03215 684999..685367 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS23_RS03220 685530..685751 - 222 WP_000692345.1 DUF987 domain-containing protein -
IQS23_RS03225 685814..686290 - 477 WP_001186710.1 RadC family protein -
IQS23_RS03230 686302..686781 - 480 WP_000860065.1 antirestriction protein -
IQS23_RS03235 686863..687681 - 819 WP_001234631.1 DUF945 domain-containing protein -
IQS23_RS03240 687781..688014 - 234 WP_001119724.1 DUF905 family protein -
IQS23_RS03245 688093..688548 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13919.89 Da        Isoelectric Point: 7.7760

>T178353 WP_032163901.1 NZ_CP063476:c684909-684535 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T178353 NZ_CP083953:c175123-174599 [Mesorhizobium sp. B2-1-8]
GTGAAGGTCACTCGCGTCGGGCCGGACGAAATCTTCCATCGCTATCTGACTCCCAAATGGGCTTTCCTGCCCACCAGCGG
TGCGGGCGCGGCGATCGATGGCGGGCGCTTCAATCGGCCGGGCGTAGAGGCGCTCTATCTGTCCCGTTCGCCGCAGACAG
CGCTCGATGAATACAGGCAGGGCGCCAGCATTGTTCCGCCAGCCACCCTTGCCGCCTACAAGATCACGCTTGCCGAAGTC
GCCGATCTGTCGCAGGGATTCGACCCGGACGTCTGGGACGACGCCTGGCAGGAATGGGATTGTGCCTGGCGCCACATCGC
TCGCATCGACAAGAAGATGCCGCCATCGTGGAAGCTCGCGGACACGGTCATCACGACCGGGCTGCGCGGCATCCTGTTTC
CGTCGCTGCGTCATGCCGGCGGCACCAACCTGGTGGTCTTTTCGGCCAATCTTGTCGACGGCGATCATGTCGAGGTTCAC
GATCCCGATCACCGGTTGCCGCAAGACCAATCGTCCTGGTCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT178353 WP_001295723.1 NZ_CP063476:c685367-684999 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT178353 NZ_CP083953:c175500-175120 [Mesorhizobium sp. B2-1-8]
ATGACCCACGCAGCACCTTCCACGGTTATCTCGGGCTTTGTCGATAGCCTGCAGGAGCCGCGCACACCCTATATCTCGCC
GAAGCGCCTGTCGGAGGCGCTGGGCGTGAAGGTTGCCAATTTGGCCCAGTTGACCGGCGTCCACCGCAACACGCTTCGTA
ATCCGTCATCGGAGCGCTTGCAGGGTCGGATGCGCGAAATGGTGAAGGTGATCTCGGCCGCGACGGAACTCACCGGCGAC
GTGGACAAGGCGATCTACTGGTATCGCAACGAACCGATCGCCGACTATGGCCATCGCACGGCGGCCGAGCTCGTCGCCGA
TAGCCAGGTCGAAGCAGTCCTGGCCTTCATCCGCGATCTCGAGAACGGGGCGCGCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L4HFA4

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References