Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2268980..2270568 Replicon chromosome
Accession NZ_CP063473
Organism Escherichia coli strain EM18-18-42

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag IQS24_RS11055 Protein ID WP_001125439.1
Coordinates 2268980..2270302 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IQS24_RS11060 Protein ID WP_001301023.1
Coordinates 2270302..2270568 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS24_RS11045 2265786..2267351 - 1566 WP_006810651.1 site-specific integrase -
IQS24_RS11050 2267338..2268732 - 1395 WP_001543774.1 site-specific integrase -
IQS24_RS11055 2268980..2270302 - 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
IQS24_RS11060 2270302..2270568 - 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IQS24_RS11065 2270791..2272191 - 1401 WP_205595690.1 autotransporter outer membrane beta-barrel domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2231275..2270568 39293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T178337 WP_001125439.1 NZ_CP063473:c2270302-2268980 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T178337 NZ_CP083950:c2583610-2583209 [Mesorhizobium sp. B4-1-4]
TTGATACGGTTCATGCTGGACACGAACATTATCAGCGACATGATCCGAAACCCGGCTGGCAAAGCCGCGAGTACCGTGTT
GCGTGTGGGGGACTCCGCAGTGTGCACCAGCATCGTGGTCGCCTCGGAATTGCGGTATGGCTGTGCCCGAAAGGGATCGG
CAAAGCTGCTCAAGAAAGTTGAGGAACTTTTGGCTGAGATTCCTGTTTTGCCGCTCGATGTGCCGGCGGACGCCGGTTAC
GGCGCCATACGCGCCGAATTGGAAGGCCTCGGCCAACCAATTGGCCACAATGATCTCTTCATTGCTGCCCATGCCTGCGC
TCTTGGTATCACGCTGGTAACGGCCAACACTGGAGAATTCACCCGGATCAGCGGGCTGAAGGTTGAAAACTGGCTGGCTT
GA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT178337 WP_001301023.1 NZ_CP063473:c2270568-2270302 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT178337 NZ_CP083950:c2583879-2583607 [Mesorhizobium sp. B4-1-4]
ATGCCCCAGCACCGCCAGTCAACGACGAGGCCCAAAGAGGCGAAGCTGTTCCGCAACAATCGAAGCCAGGCAGTGCGCAT
TCCCGTCGAGTTCGAGCTTCCGGGCGACAGGGTCCTGATCAGTCGGGAAGGCGACCGTCTGGTCATCGAGCCGGTTCGCA
GGCCGGGTCTCACCGCGCTGCTTGCCCAGTGGGCGAACGAGCTACCGCTCGGTCCCGAGGACGATTTCCCTGAATTCGAC
GACGCGCCTGTCAAACCCGAGGACATTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References