Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 123785..124320 Replicon plasmid pEM22-18-53_3
Accession NZ_CP063462
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name relE Uniprot ID V0VJJ7
Locus tag IQS26_RS23775 Protein ID WP_000222760.1
Coordinates 124033..124320 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag IQS26_RS23770 Protein ID WP_001132900.1
Coordinates 123785..124036 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS23730 118912..119472 + 561 WP_203079851.1 fertility inhibition protein FinO -
IQS26_RS23735 119608..119820 + 213 WP_001299730.1 ANR family transcriptional regulator -
IQS26_RS23740 120066..120140 + 75 Protein_111 endonuclease -
- 120396..120457 - 62 NuclAT_1 - -
- 120396..120457 - 62 NuclAT_1 - -
- 120396..120457 - 62 NuclAT_1 - -
- 120396..120457 - 62 NuclAT_1 - -
IQS26_RS23745 120444..120650 + 207 WP_001351576.1 type I toxin-antitoxin system Hok family toxin -
IQS26_RS23750 120934..121191 + 258 WP_000083845.1 replication regulatory protein RepA -
IQS26_RS23755 121423..121497 + 75 WP_001442103.1 RepA leader peptide Tap -
IQS26_RS23760 121490..121972 + 483 WP_001273588.1 hypothetical protein -
IQS26_RS23765 121965..122822 + 858 WP_000774297.1 incFII family plasmid replication initiator RepA -
IQS26_RS23770 123785..124036 + 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IQS26_RS23775 124033..124320 + 288 WP_000222760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IQS26_RS23780 124760..125107 - 348 Protein_119 IS1-like element IS1A family transposase -
IQS26_RS23785 125196..126218 + 1023 WP_000255956.1 IS21-like element IS100 family transposase -
IQS26_RS23790 126215..126997 + 783 WP_001442137.1 IS21-like element IS100kyp family helper ATPase IstB -
IQS26_RS23795 127052..127416 - 365 Protein_122 IS1 family transposase -
IQS26_RS23800 127516..128737 + 1222 Protein_123 ISL3 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid sitABCD vat / iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..169293 169293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-83)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11105.15 Da        Isoelectric Point: 10.5832

>T178302 WP_000222760.1 NZ_CP063462:124033-124320 [Escherichia coli]
MTYTVKFRDDALKEWLKLDKSIQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T178302 NZ_CP083922:c47090-46227 [Enterococcus faecium]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAATACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
AGATAAAGGGTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGATTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGGATTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT178302 WP_001132900.1 NZ_CP063462:123785-124036 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT178302 NZ_CP083922:c47364-47092 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0VJJ7


Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References