Detailed information of TA system TA178292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3504467..3506055
• Replicon: chromosome
• Accession: NZ_CP063459
• Organism: Escherichia coli strain EM22-18-53

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: IQS26_RS16765
• Protein ID: WP_001125463.1
• Coordinates: 3504733..3506055 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IQS26_RS16760
• Protein ID: WP_001296726.1
• Coordinates: 3504467..3504733 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS26_RS16760	3504467..3504733	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IQS26_RS16765	3504733..3506055	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
IQS26_RS16770	3506367..3506575	+	209	Protein_3263	helix-turn-helix transcriptional regulator	-
IQS26_RS16775	3507007..3507570	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
IQS26_RS16780	3507931..3508641	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA	3504467..3521891	17424

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T178292 WP_001125463.1 NZ_CP063459:3504733-3506055 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T178292 NZ_CP083911:c2872219-2871938 [Tepidimonas taiwanensis]
ATGAGGATCCTGTTCTGGACGCCGGAGGCGATTCAGGACCGCGTCGACATCTACGACCACATCGAGGCCGACAATCCGGC
CGCCGCACTGGCCCTCGATGAGCGGTTATCCGGGGCGGCGGGTCGCTTGATCGAGCATCCCGGCCTGGGTCGCCCTGGTC
GCGTCGCTGGTACCCGCGAGCTGGTGGTCCATCCAAACTATCTCCTGGTCTACGACATCACCGATGACCAGGTGCGCGTG
CTGCGCGTGTTGCACGCGGCGCGGCAGTGGCCTTCAAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT178292 WP_001296726.1 NZ_CP063459:3504467-3504733 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT178292 NZ_CP083911:c2872506-2872216 [Tepidimonas taiwanensis]
ATGAGCGAAAGCACCTTCACGTTCCGGGTCGACCCGGCGCTGAAATCCGCGTTCTCTGCCGCAGCCAAAAAAATGGACCG
CAACGCCGCGCAGCTCCTGCGTGACTTCATGCGCGACGTCGTTCGCCAGCAGCAGGAAACCACGGCACACGACGCCTGGT
TCCGACGCGCGGTCCAGACAGGGCTGGACTCTGCCAACGCCGGTCGCCTCATCCCCTCGGCGGAAGTCGAAGCACGGTTT
GCCGCCAAACGCGCCGCAACCCGCCAACGGCTTGAAGCCGCCGCCGAATGA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0