Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2103597..2104432 Replicon chromosome
Accession NZ_CP063459
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1V3VXN0
Locus tag IQS26_RS10115 Protein ID WP_000854801.1
Coordinates 2103597..2103974 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1V3VXQ4
Locus tag IQS26_RS10120 Protein ID WP_001360188.1
Coordinates 2104064..2104432 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS10085 2099247..2101088 + 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -
IQS26_RS10090 2101167..2101673 - 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
IQS26_RS10100 2101973..2102818 - 846 Protein_1959 DUF4942 domain-containing protein -
IQS26_RS10105 2102903..2103100 - 198 WP_000839269.1 DUF957 domain-containing protein -
IQS26_RS10110 2103112..2103600 - 489 WP_000761658.1 hypothetical protein -
IQS26_RS10115 2103597..2103974 - 378 WP_000854801.1 type IV toxin-antitoxin system toxin CbtA Toxin
IQS26_RS10120 2104064..2104432 - 369 WP_001360188.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS26_RS10125 2104482..2105126 - 645 WP_000086744.1 hypothetical protein -
IQS26_RS10130 2105141..2105362 - 222 WP_000692334.1 DUF987 domain-containing protein -
IQS26_RS10135 2105431..2105907 - 477 WP_001186725.1 RadC family protein -
IQS26_RS10140 2105923..2106408 - 486 WP_000214418.1 antirestriction protein -
IQS26_RS10145 2106499..2107317 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage blaTEM-1B / aac(3)-IVa / aph(4)-Ia / floR / fosA3 rfaE 2061041..2148514 87473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13881.87 Da        Isoelectric Point: 7.3219

>T178279 WP_000854801.1 NZ_CP063459:c2103974-2103597 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T178279 NZ_CP083911:170228-170581 [Tepidimonas taiwanensis]
TTGAGGACCTCTGACCCCCCTGGCGCGCAGCCACCGCAGCCGTACCGCTTGCATTTCATGCCGGAGGCACTGGAGGAGTG
GCACCGTCTGGATGGATCGGTCAAGGCCAGCCTGAAAAAGCTGCTCAAAAAGCGTCTCGTACAGCCTCATGTACCCGGTG
GTGCCCTGACGGGTCCGTTGGCGGGCTGCTACAAAATCAAGTTGCGCAAGCAAGGGGTGCGGTTGGTGTACGCGGTCGAG
GACGACCGCCCCATCGTCCTGGTGCTGGCGATCGACAGACGGGAGCGCGACCAGGTTTACCGATCGGCCCTCGTACGCGT
CTCTGCCCCGCCGGATCGGCCCAAAGGGCGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.27 Da        Isoelectric Point: 6.2044

>AT178279 WP_001360188.1 NZ_CP063459:c2104432-2104064 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGVTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT178279 NZ_CP083911:169990-170241 [Tepidimonas taiwanensis]
ATGGAAACCATACTGGCCGATGTCGCCGTCAGCATGTCGGAATTCAAGAAGAACCCTGCCGCGGTGCTGCGGCACGCACA
CCGTCGTCCGGTGGCGGTCTTGAGTCACAACCGCCCCGCGTTCTACATGATCGAACCCCGACTGTTCGAGGACATCATGG
AAGCGTTGGCGGATCAGGATCTGTACCGTCGGGCCGCCAGCCGTCTGGCCGAGAAAGGGCGGGCCGTCGAGGTGAACCTT
GAGGACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V3VXN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1V3VXQ4

References