Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1889030..1889684 Replicon chromosome
Accession NZ_CP063459
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag IQS26_RS09010 Protein ID WP_000244777.1
Coordinates 1889030..1889437 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag IQS26_RS09015 Protein ID WP_000354046.1
Coordinates 1889418..1889684 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS08990 1884987..1886720 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
IQS26_RS08995 1886726..1887436 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IQS26_RS09000 1887461..1888357 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
IQS26_RS09005 1888469..1888990 + 522 WP_001055874.1 flavodoxin FldB -
IQS26_RS09010 1889030..1889437 - 408 WP_000244777.1 toxin CptA Toxin
IQS26_RS09015 1889418..1889684 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
IQS26_RS09020 1889927..1890907 + 981 WP_000886061.1 tRNA-modifying protein YgfZ -
IQS26_RS09025 1890984..1891643 - 660 WP_000250274.1 hemolysin III family protein -
IQS26_RS09030 1891807..1892118 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
IQS26_RS09035 1892163..1893596 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
IQS26_RS09040 1893653..1894396 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T178277 WP_000244777.1 NZ_CP063459:c1889437-1889030 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T178277 NZ_CP083901:30580-31074 [Zymomonas mobilis]
GTGACAATAACAGCTCCAGAATTAGTATCCCCAGAACATCAAGTTGACTTATTTCAGTCCGGTGTAGAGAGCCTTGATCT
ATGGTTAAAAAAGCGCGCTTTGAAAAATCAAATGACAGGAGCCTCTCGTACCTTTGTAGCCTGTAAAAATCGACGGGTGA
TAGCCTATTATGCTCTAGCATCTAGCGCTATCACTATAAAATCAGCCCATGGACGATTTAGGCGTAATATGCCAGATCCT
ATTCCTGTTGTCGTTTTAGGGCGGCTTGCTATTGATCAATCTTTACATAACCAAGGCGTTGGACGAGCAATGGTAAGGGA
TGCAGCCTTAAGGATAATACAGGCAGCTGATACTATCGGAATTAGAGGTATGCTCGTTCATGCGCTATCTGATGAAGCCA
AATCTTTCTACGAACATATCGGTTTCGAACCGTCTCCAATCGACCCAATGATGTTGATGGTTACATTAGCCGATTTAAAG
TCGAGCCTTGCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT178277 WP_000354046.1 NZ_CP063459:c1889684-1889418 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178277 NZ_CP083901:30287-30583 [Zymomonas mobilis]
ATGACAGCTGCAACAACGATACCTTCTCCAAATAAGCGAGAAGCGCTAAATATCAGAATTAAACCGGAAGAACGGGATTT
AATAGATCGAGCAGCAAAGATTCAGAGAAAAAGTCGTACTAATTTTGTATTGGAAGCTGCCTGTAGAGCCGCAGAAGAAG
CGCTTTTCGATCAATGTCTCATCTCTGTTGATCCAAAGGCGTATACTGATTTTTTAATGCGCCTCGATATGCCGCCACGC
CCTAATGATCGGCTGCAAAAAACCATGCAAACGGTAGCGCCGTGGGATGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References