178275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1338037..1338837 Replicon chromosome
Accession NZ_CP063459
Organism Escherichia coli strain EM22-18-53

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag IQS26_RS06270 Protein ID WP_000342449.1
Coordinates 1338310..1338837 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag IQS26_RS06265 Protein ID WP_001277108.1
Coordinates 1338037..1338303 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS26_RS06245 1333694..1334362 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
IQS26_RS06250 1334355..1335413 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
IQS26_RS06255 1335658..1336512 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
IQS26_RS06260 1336784..1337887 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
IQS26_RS06265 1338037..1338303 + 267 WP_001277108.1 DUF1778 domain-containing protein Antitoxin
IQS26_RS06270 1338310..1338837 + 528 WP_000342449.1 GNAT family N-acetyltransferase Toxin
IQS26_RS06275 1338834..1339217 - 384 WP_000778777.1 aspartate 1-decarboxylase autocleavage activator PanM -
IQS26_RS06280 1339641..1340750 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
IQS26_RS06285 1340798..1341724 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
IQS26_RS06290 1341721..1342998 + 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
IQS26_RS06295 1342995..1343762 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T178275 WP_000342449.1 NZ_CP063459:1338310-1338837 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T178275 NZ_CP083900:c33128-32859 [Zymomonas mobilis]
GTGCTAACGCCTATCCGATCGAGCAAATTCAAGAAAGACATAAAAAAATTACAGAAGCGAGGTAAGGATATGGAAAAATT
AAAAAAAGCCATTCTTTACCTGATTAATGAACAAGCCTTACCACCAGCCTACCGAAGCCATGTTTTAAGTGGCGATTGGT
CGGGTTACTACGATTTGCATTTGGAACCTGACTGGCTCCTGCTCTATAAAATAGCTGATATGGAATTGCATCTAGCGCGA
ACAGGCAGCCATTCAGATGTTTTTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT178275 WP_001277108.1 NZ_CP063459:1338037-1338303 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT178275 NZ_CP083900:c33387-33130 [Zymomonas mobilis]
ATGAAAGCAGATTCTGTTGTTAGAGCACGCATCCCAACCTTGACCAAGGAAGCCGCGATTAAAACTTTGGAGCAGATGGG
ACTTAGTATTTCTGATGCTATCCGGTTGCTTATGACTAAAATCGCCAATGAGCAACGTCTTCCCTTTTCTGTTGAATTAC
CAACGGTGGAAACCAAAAAAGCGATTATCGAATTGGAAAATGGAAAAGGTAAGACTTTTAAAAATGCAGATGCTCTGTTC
GAGGATTTAGGTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CN24

References