Detailed information of TA system TA178272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 334194..335014
• Replicon: chromosome
• Accession: NZ_CP063459
• Organism: Escherichia coli strain EM22-18-53

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: IQS26_RS01540
• Protein ID: WP_001054379.1
• Coordinates: 334194..334451 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: IQS26_RS01545
• Protein ID: WP_000123957.1
• Coordinates: 334463..335014 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS26_RS01520	329481..330587	+	1107	WP_001295733.1	N-acetylneuraminate epimerase	-
IQS26_RS01525	330651..331631	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
IQS26_RS01530	332214..333440	-	1227	Protein_297	DNA helicase	-
IQS26_RS01535	333518..333817	+	300	WP_001332034.1	GNAT family N-acetyltransferase	-
IQS26_RS01540	334194..334451	+	258	WP_001054379.1	YjhX family toxin	Toxin
IQS26_RS01545	334463..335014	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
IQS26_RS01550	335066..335812	+	747	WP_001588380.1	class I SAM-dependent methyltransferase	-
IQS26_RS01555	335940..336200	+	261	WP_000077646.1	hypothetical protein	-
IQS26_RS01560	336238..336354	+	117	Protein_303	VOC family protein	-
IQS26_RS01565	336599..337720	+	1122	WP_000010833.1	M42 family metallopeptidase	-
IQS26_RS01570	337717..337995	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
IQS26_RS01575	338007..339320	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	325615..343235	17620

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T178272 WP_001054379.1 NZ_CP063459:334194-334451 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T178272 NZ_CP083890:c28195-28043 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT178272 WP_000123957.1 NZ_CP063459:334463-335014 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT178272 NZ_CP083890:28245-28307 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: B6I030