Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1785887..1786770 Replicon chromosome
Accession NZ_CP063456
Organism Pseudomonas shirazica strain A28

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag IMX18_RS08250 Protein ID WP_013973162.1
Coordinates 1786384..1786770 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag IMX18_RS08245 Protein ID WP_217191286.1
Coordinates 1785887..1786336 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMX18_RS08220 1781255..1782454 + 1200 WP_061304062.1 sugar transporter -
IMX18_RS08225 1782594..1783178 - 585 WP_054572088.1 LysE family translocator -
IMX18_RS08230 1783229..1784059 - 831 WP_217191285.1 AraC family transcriptional regulator -
IMX18_RS08235 1784107..1785030 - 924 WP_054572087.1 LysR family transcriptional regulator -
IMX18_RS08240 1785135..1785788 + 654 WP_054572086.1 oxygen-insensitive NAD(P)H-dependent nitroreductase NfsB -
IMX18_RS08245 1785887..1786336 + 450 WP_217191286.1 DUF2384 domain-containing protein Antitoxin
IMX18_RS08250 1786384..1786770 + 387 WP_013973162.1 RES family NAD+ phosphorylase Toxin
IMX18_RS08255 1786778..1787932 - 1155 WP_054572084.1 aminotransferase class V-fold PLP-dependent enzyme -
IMX18_RS08260 1788104..1789030 - 927 WP_015270849.1 LysR family transcriptional regulator -
IMX18_RS08265 1789171..1790400 + 1230 WP_015270848.1 acyl-CoA dehydrogenase -
IMX18_RS08270 1790478..1791542 - 1065 WP_015270847.1 TerC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-120)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(97-146)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14226.21 Da        Isoelectric Point: 5.0980

>T178270 WP_013973162.1 NZ_CP063456:1786384-1786770 [Pseudomonas shirazica]
MRVSGRWHQAGRPVVYAATSPAGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQPGWSSQTELTRGLGNRF
LDECSALLLPVPSAIMPSTTNYLFNPRHPQANSARLEVEDFTPDSRLF

Download         Length: 387 bp

>T178270 NZ_CP083889:180533-180949 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGATGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17018.62 Da        Isoelectric Point: 6.3405

>AT178270 WP_217191286.1 NZ_CP063456:1785887-1786336 [Pseudomonas shirazica]
MLAEVLRDNGYHEYRARLHALLEIPELASDFEIHTRITHGFAATWLVKLTELGVFTPLERDQIIPLRTLKTRIERDQPLT
VEESDRLFRSAHITAMAEAVFGEAGKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp

>AT178270 NZ_CP083889:180306-180536 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References