Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5662798..5663429 Replicon chromosome
Accession NZ_CP063455
Organism Pseudomonas protegens strain PC-578039

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IP586_RS25640 Protein ID WP_102860369.1
Coordinates 5662798..5663196 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IP586_RS25645 Protein ID WP_102860368.1
Coordinates 5663196..5663429 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP586_RS25620 5659195..5659557 + 363 WP_267268850.1 hypothetical protein -
IP586_RS25625 5659567..5660136 - 570 WP_102880836.1 hypothetical protein -
IP586_RS25630 5660273..5662321 - 2049 WP_110596396.1 c-type cytochrome -
IP586_RS25635 5662662..5662775 + 114 WP_253084929.1 DUF2938 domain-containing protein -
IP586_RS25640 5662798..5663196 - 399 WP_102860369.1 tRNA(fMet)-specific endonuclease VapC Toxin
IP586_RS25645 5663196..5663429 - 234 WP_102860368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IP586_RS25650 5663797..5665044 + 1248 WP_267268851.1 aspartate aminotransferase family protein -
IP586_RS25655 5665069..5665653 - 585 WP_102880841.1 hypothetical protein -
IP586_RS25660 5665658..5666098 - 441 WP_199012301.1 DUF3592 domain-containing protein -
IP586_RS25665 5666223..5666453 - 231 WP_267268852.1 amidohydrolase family protein -
IP586_RS25670 5666623..5667750 - 1128 WP_110652277.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15077.41 Da        Isoelectric Point: 7.9042

>T178267 WP_102860369.1 NZ_CP063455:c5663196-5662798 [Pseudomonas protegens]
MLKYMLDTNICIFTIKNKPEQVRDAFRRHQGRLCISTITLMELIYGAEKSAIPERNLSRVESFVARLQVLDYDDVAAIHS
GQLHAELARQGKQIGPYDQLIAGHARSLGLTLITNNLREFERVPGLRVEDWV

Download         Length: 399 bp

>T178267 NZ_CP083889:c110867-110718 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8787.73 Da        Isoelectric Point: 4.2342

>AT178267 WP_102860368.1 NZ_CP063455:c5663429-5663196 [Pseudomonas protegens]
METGSVFKSNRSQAIRMPKAVALPDDVTRVDIVAIGRTRIITPAGESWDSWFDEDDRVSADFMNERDQPAEQVREEF

Download         Length: 234 bp

>AT178267 NZ_CP083889:110911-110972 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References