Detailed information of TA system TA178267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 5662798..5663429
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IP586_RS25640
• Protein ID: WP_102860369.1
• Coordinates: 5662798..5663196 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IP586_RS25645
• Protein ID: WP_102860368.1
• Coordinates: 5663196..5663429 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS25620	5659195..5659557	+	363	WP_267268850.1	hypothetical protein	-
IP586_RS25625	5659567..5660136	-	570	WP_102880836.1	hypothetical protein	-
IP586_RS25630	5660273..5662321	-	2049	WP_110596396.1	c-type cytochrome	-
IP586_RS25635	5662662..5662775	+	114	WP_253084929.1	DUF2938 domain-containing protein	-
IP586_RS25640	5662798..5663196	-	399	WP_102860369.1	tRNA(fMet)-specific endonuclease VapC	Toxin
IP586_RS25645	5663196..5663429	-	234	WP_102860368.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
IP586_RS25650	5663797..5665044	+	1248	WP_267268851.1	aspartate aminotransferase family protein	-
IP586_RS25655	5665069..5665653	-	585	WP_102880841.1	hypothetical protein	-
IP586_RS25660	5665658..5666098	-	441	WP_199012301.1	DUF3592 domain-containing protein	-
IP586_RS25665	5666223..5666453	-	231	WP_267268852.1	amidohydrolase family protein	-
IP586_RS25670	5666623..5667750	-	1128	WP_110652277.1	UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15077.41 Da
• Isoelectric Point: 7.9042

>T178267 WP_102860369.1 NZ_CP063455:c5663196-5662798 [Pseudomonas protegens]
MLKYMLDTNICIFTIKNKPEQVRDAFRRHQGRLCISTITLMELIYGAEKSAIPERNLSRVESFVARLQVLDYDDVAAIHS
GQLHAELARQGKQIGPYDQLIAGHARSLGLTLITNNLREFERVPGLRVEDWV

Nucleotide

• Length: 399 bp

>T178267 NZ_CP083889:c110867-110718 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8787.73 Da
• Isoelectric Point: 4.2342

>AT178267 WP_102860368.1 NZ_CP063455:c5663429-5663196 [Pseudomonas protegens]
METGSVFKSNRSQAIRMPKAVALPDDVTRVDIVAIGRTRIITPAGESWDSWFDEDDRVSADFMNERDQPAEQVREEF

Nucleotide

• Length: 234 bp

>AT178267 NZ_CP083889:110911-110972 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT