Detailed information of TA system TA178265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4430501..4431368
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IP586_RS19980
• Protein ID: WP_103407584.1
• Coordinates: 4430501..4430680 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IP586_RS19985
• Protein ID: WP_267268532.1
• Coordinates: 4430751..4431368 (+)
• Length: 206 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS19945	4425581..4426999	-	1419	WP_267268530.1	DUF4055 domain-containing protein	-
IP586_RS19950	4426996..4428297	-	1302	WP_159892771.1	terminase family protein	-
IP586_RS19955	4428284..4428745	-	462	WP_159892769.1	DUF2280 domain-containing protein	-
IP586_RS19960	4428778..4429401	-	624	WP_267268531.1	putative metallopeptidase	-
IP586_RS19965	4429475..4429669	+	195	WP_159892765.1	hypothetical protein	-
IP586_RS19970	4429730..4430074	-	345	WP_159892763.1	hypothetical protein	-
IP586_RS19975	4430071..4430400	-	330	WP_103407585.1	MFS transporter	-
IP586_RS19980	4430501..4430680	+	180	WP_103407584.1	type II toxin-antitoxin system HicA family toxin	Toxin
IP586_RS19985	4430751..4431368	+	618	WP_267268532.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IP586_RS19990	4431992..4432687	-	696	WP_267268533.1	hypothetical protein	-
IP586_RS19995	4432684..4433295	-	612	WP_267268534.1	recombination protein NinG	-
IP586_RS20000	4433292..4433879	-	588	WP_267268535.1	DUF1367 family protein	-
IP586_RS20005	4433872..4434690	-	819	WP_267268536.1	hypothetical protein	-
IP586_RS20010	4434647..4435570	-	924	WP_267268537.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	xcpR / xcpT	4388958..4455418	66460

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-62)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6665.70 Da
• Isoelectric Point: 10.8214

>T178265 WP_103407584.1 NZ_CP063455:4430501-4430680 [Pseudomonas protegens]
MKYSEFRRWLKAQGVTFEAAKGSHFKITAPNGNQTVFADHGSKEMKEPTRKGIIKQLGL

Nucleotide

• Length: 180 bp

>T178265 NZ_CP083888:c4309652-4309479 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 206 a.a.
• Molecular weight: 22580.74 Da
• Isoelectric Point: 4.7984

>AT178265 WP_267268532.1 NZ_CP063455:4430751-4431368 [Pseudomonas protegens]
MFDYPVTIHEDENPGVAVTCDDLPEFNSAGDDVADALRESVDGIETALSIYVDQRRVIPKASDPKPGQHVVRLPAVTVAK
IVLWNEMMARDMRKADLCRLLGLAQTQGDRLVDFLHTSKMEAIEKALNALGRRLVVTTESFARYEVIYTQDGARKSFFLM
YNDGLNPWAALLSGLKLSAPKDLESPSAEQICRAHGISDAFGIAT

Nucleotide

• Length: 618 bp

>AT178265 NZ_CP083888:c4309976-4309680 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG