Detailed information of TA system TA178263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2591656..2592275
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2J7U9Z9
• Locus tag: IP586_RS11995
• Protein ID: WP_041120604.1
• Coordinates: 2592093..2592275 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IP586_RS11990
• Protein ID: WP_236204227.1
• Coordinates: 2591656..2592057 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS11975	2589616..2589819	+	204	WP_267269725.1	hypothetical protein	-
IP586_RS11980	2590724..2591110	+	387	WP_267269726.1	hypothetical protein	-
IP586_RS11985	2591192..2591545	+	354	WP_267269727.1	hypothetical protein	-
IP586_RS11990	2591656..2592057	-	402	WP_236204227.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IP586_RS11995	2592093..2592275	-	183	WP_041120604.1	type II toxin-antitoxin system HicA family toxin	Toxin
IP586_RS12000	2592673..2592933	-	261	WP_267269728.1	DUF6429 family protein	-
IP586_RS12005	2593066..2594106	-	1041	WP_267269729.1	hypothetical protein	-
IP586_RS12010	2594125..2594826	+	702	WP_267270081.1	hypothetical protein	-
IP586_RS12015	2594803..2595175	+	373	Protein_2358	IS5/IS1182 family transposase	-
IP586_RS12020	2595169..2595379	+	211	Protein_2359	IS3 family transposase	-
IP586_RS12025	2595665..2595781	+	117	Protein_2360	hypothetical protein	-
IP586_RS12030	2596010..2596171	+	162	Protein_2361	DapH/DapD/GlmU-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6885.09 Da
• Isoelectric Point: 11.2684

>T178263 WP_041120604.1 NZ_CP063455:c2592275-2592093 [Pseudomonas protegens]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAELI

Nucleotide

• Length: 183 bp

>T178263 NZ_CP083888:3527800-3528018 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14610.63 Da
• Isoelectric Point: 5.1666

>AT178263 WP_236204227.1 NZ_CP063455:c2592057-2591656 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFETAYSAAIEIAHVMLEELARAGHAIPLPSPTRKHRANPDFEGMGWGM
LDIDIAPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT178263 NZ_CP083888:3527400-3527774 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A2J7U9Z9