Detailed information of TA system TA178261

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1714500..1715013
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IP586_RS07910
• Protein ID: WP_110595048.1
• Coordinates: 1714500..1714784 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IP586_RS07915
• Protein ID: WP_092320301.1
• Coordinates: 1714774..1715013 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS07885	1709516..1710403	-	888	WP_267269508.1	dihydrodipicolinate synthase family protein	-
IP586_RS07890	1710435..1711217	-	783	WP_102878683.1	aldolase	-
IP586_RS07895	1711379..1711921	+	543	WP_110651880.1	XRE family transcriptional regulator	-
IP586_RS07900	1712123..1713142	-	1020	WP_267270023.1	DUF4917 family protein	-
IP586_RS07905	1713300..1714448	+	1149	WP_102878685.1	L-threonine dehydrogenase	-
IP586_RS07910	1714500..1714784	-	285	WP_110595048.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IP586_RS07915	1714774..1715013	-	240	WP_092320301.1	ribbon-helix-helix protein, CopG family	Antitoxin
IP586_RS07920	1715214..1715951	+	738	WP_253083877.1	hypothetical protein	-
IP586_RS07925	1715962..1716339	+	378	WP_267269509.1	hypothetical protein	-
IP586_RS07930	1716315..1716731	+	417	WP_267269510.1	fosfomycin resistance glutathione transferase	-
IP586_RS07935	1716858..1717496	+	639	WP_102878689.1	LysE family translocator	-
IP586_RS07940	1717605..1718954	+	1350	WP_267269511.1	GGDEF domain-containing protein	-
IP586_RS07945	1719112..1719636	+	525	WP_267269512.1	DUF4142 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11040.72 Da
• Isoelectric Point: 11.8691

>T178261 WP_110595048.1 NZ_CP063455:c1714784-1714500 [Pseudomonas protegens]
MRIEWLRSALNNLDAEARHIAQDDPRAAGEFVRALLISIEQLARFPSSGREGRLPGTREWVVPGWPYLIPYRVRGDRLQI
LRIFHTRRQPPARW

Nucleotide

• Length: 285 bp

>T178261 NZ_CP083888:2730008-2730115 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8604.71 Da
• Isoelectric Point: 4.3085

>AT178261 WP_092320301.1 NZ_CP063455:c1715013-1714774 [Pseudomonas protegens]
MSIMSLRLPDELAETLALLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALNEADAGDFASAEEVAAIAGKWTDNAH

Nucleotide

• Length: 240 bp

>AT178261 NZ_CP083888:c2729961-2729895 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT