Detailed information of TA system TA178259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 392162..392678
• Replicon: chromosome
• Accession: NZ_CP063455
• Organism: Pseudomonas protegens strain PC-578039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IP586_RS01780
• Protein ID: WP_102862559.1
• Coordinates: 392397..392678 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IP586_RS01775
• Protein ID: WP_253085824.1
• Coordinates: 392162..392407 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP586_RS01755	387245..389443	-	2199	WP_267269186.1	outer membrane assembly lipoprotein YfiO	-
IP586_RS01760	389703..391259	+	1557	WP_267270012.1	glycosyltransferase family 39 protein	-
IP586_RS01765	391376..391837	+	462	WP_102862557.1	YbaK/EbsC family protein	-
IP586_RS01770	391852..392097	+	246	WP_102862558.1	DUF2789 domain-containing protein	-
IP586_RS01775	392162..392407	+	246	WP_253085824.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IP586_RS01780	392397..392678	+	282	WP_102862559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IP586_RS01785	392821..393249	+	429	WP_110595253.1	winged helix DNA-binding protein	-
IP586_RS01790	393246..395333	+	2088	WP_267269187.1	FUSC family protein	-
IP586_RS01795	395330..395539	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
IP586_RS01800	395536..396426	+	891	WP_267269188.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10825.74 Da
• Isoelectric Point: 10.3689

>T178259 WP_102862559.1 NZ_CP063455:392397-392678 [Pseudomonas protegens]
MTYRLEFLPSAHKEWSKLGHTLREQFKKKLAERLEVPRIPADALHGLADCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGAVYEQARKR

Nucleotide

• Length: 282 bp

>T178259 NZ_CP083888:2062723-2062826 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGGCCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8754.07 Da
• Isoelectric Point: 4.5164

>AT178259 WP_253085824.1 NZ_CP063455:392162-392407 [Pseudomonas protegens]
MQSILADKAVSVSELKKNPSAVLNGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIVRARSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT178259 NZ_CP083888:c2062864-2062593 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGCCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT