Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4942455..4942996 Replicon chromosome
Accession NZ_CP063450
Organism Rhodococcus pyridinivorans strain 5Ap

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag INP59_RS22985 Protein ID WP_138845823.1
Coordinates 4942455..4942754 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag INP59_RS22990 Protein ID WP_138844995.1
Coordinates 4942754..4942996 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP59_RS22955 4938109..4938924 + 816 WP_138844991.1 SDR family oxidoreductase -
INP59_RS22960 4939082..4939822 + 741 WP_138844993.1 FadR family transcriptional regulator -
INP59_RS22965 4940090..4940450 - 361 Protein_4523 protein kinase -
INP59_RS22970 4940553..4941395 - 843 Protein_4524 hypothetical protein -
INP59_RS22975 4941391..4941687 + 297 Protein_4525 hypothetical protein -
INP59_RS22980 4941709..4942077 + 369 WP_138845821.1 dihydrofolate reductase family protein -
INP59_RS22985 4942455..4942754 - 300 WP_138845823.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
INP59_RS22990 4942754..4942996 - 243 WP_138844995.1 antitoxin Antitoxin
INP59_RS22995 4943440..4944354 + 915 WP_138844997.1 LLM class flavin-dependent oxidoreductase -
INP59_RS23000 4944955..4945506 - 552 WP_138844999.1 TetR/AcrR family transcriptional regulator -
INP59_RS23005 4945681..4946196 + 516 WP_138845825.1 thioesterase family protein -
INP59_RS23010 4946688..4947491 + 804 WP_006941794.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10529.25 Da        Isoelectric Point: 8.0583

>T178255 WP_138845823.1 NZ_CP063450:c4942754-4942455 [Rhodococcus pyridinivorans]
MRPIHAAKLDKTRPVLVLTRELVRPHLGRVTVAPITGTVRGLSTEVPVGPANGLEKDSVVSCDNIVTIPVSALGRSLGFF
FPAQEAALSEAIRAAFDLE

Download         Length: 300 bp

>T178255 NZ_CP083888:1091638-1091949 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9031.14 Da        Isoelectric Point: 4.9060

>AT178255 WP_138844995.1 NZ_CP063450:c4942996-4942754 [Rhodococcus pyridinivorans]
MSTQIAVRLPDEIVAFVDEEVREHRAPSRAALVLRALERERRRRIAARDVEILSRARGEADPDEFDGLARYAAGLSSDLE

Download         Length: 243 bp

>AT178255 NZ_CP083888:1091946-1092365 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References