Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2682960..2683912 Replicon chromosome
Accession NZ_CP063450
Organism Rhodococcus pyridinivorans strain 5Ap

Toxin (Protein)


Gene name pezT Uniprot ID H0JT30
Locus tag INP59_RS12490 Protein ID WP_006552790.1
Coordinates 2682960..2683529 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7M2XIK8
Locus tag INP59_RS12495 Protein ID WP_016696422.1
Coordinates 2683526..2683912 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INP59_RS12490 2682960..2683529 - 570 WP_006552790.1 zeta toxin family protein Toxin
INP59_RS12495 2683526..2683912 - 387 WP_016696422.1 hypothetical protein Antitoxin
INP59_RS12500 2684120..2685190 + 1071 WP_138843340.1 class I SAM-dependent methyltransferase -
INP59_RS12505 2685260..2685625 + 366 WP_193902057.1 HNH endonuclease -
INP59_RS12510 2687324..2688256 - 933 WP_193902058.1 TAXI family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-104)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20552.71 Da        Isoelectric Point: 10.6895

>T178254 WP_006552790.1 NZ_CP063450:c2683529-2682960 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T178254 NZ_CP083888:1021891-1022226 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14038.49 Da        Isoelectric Point: 4.7096

>AT178254 WP_016696422.1 NZ_CP063450:c2683912-2683526 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Download         Length: 387 bp

>AT178254 NZ_CP083888:1021643-1021891 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7RLW6

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2XIK8

References