Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 160912..161462 Replicon plasmid p2
Accession NZ_CP063447
Organism Novosphingobium sp. ES2-1

Toxin (Protein)


Gene name parE Uniprot ID A0A7M2XFC8
Locus tag IM701_RS18865 Protein ID WP_039338748.1
Coordinates 161160..161462 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7M2XF50
Locus tag IM701_RS18860 Protein ID WP_039338749.1
Coordinates 160912..161157 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM701_RS18840 156498..157280 + 783 WP_193829003.1 alpha/beta fold hydrolase -
IM701_RS18845 157834..158436 + 603 WP_039338720.1 helix-turn-helix transcriptional regulator -
IM701_RS18850 158433..159647 + 1215 WP_039338718.1 type II toxin-antitoxin system HipA family toxin -
IM701_RS18855 159807..160783 + 977 Protein_151 IS110 family transposase -
IM701_RS18860 160912..161157 + 246 WP_039338749.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IM701_RS18865 161160..161462 + 303 WP_039338748.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IM701_RS18870 161926..162237 - 312 WP_193829004.1 hypothetical protein -
IM701_RS18875 162493..164115 + 1623 WP_193829005.1 hypothetical protein -
IM701_RS18880 164228..164752 + 525 WP_193829006.1 hypothetical protein -
IM701_RS18885 164897..166051 - 1155 WP_193829007.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fcl / gmd 1..336628 336628


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(3-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11473.97 Da        Isoelectric Point: 5.9705

>T178251 WP_039338748.1 NZ_CP063447:161160-161462 [Novosphingobium sp. ES2-1]
VPRFRLTRAAAEDLTAIFLQGIEQFGLPQADTYHEGLSAIFEFLADYPQAARLREEISPPVRVHPYKAHLVIYDVGDEDK
VIILRVRHGREDWISSNYHG

Download         Length: 303 bp

>T178251 NZ_CP083888:c601834-601370 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9087.14 Da        Isoelectric Point: 4.5457

>AT178251 WP_039338749.1 NZ_CP063447:160912-161157 [Novosphingobium sp. ES2-1]
MATMNISLPDPMKQWVEAQADTGRYSNASDYVRDLIRRDQERADKVAAMQRLVDEARASGLSDETMADIRTRAISQADLQ
A

Download         Length: 246 bp

>AT178251 NZ_CP083888:c602169-601834 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2XFC8

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2XF50

References