Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2843886..2844683 Replicon chromosome
Accession NZ_CP063441
Organism Enterobacter asburiae strain SD4L

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag INS04_RS13380 Protein ID WP_172421424.1
Coordinates 2843886..2844386 (-) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag INS04_RS13385 Protein ID WP_193804637.1
Coordinates 2844414..2844683 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INS04_RS13350 2839469..2840158 + 690 WP_029742091.1 pyrimidine utilization protein B -
INS04_RS13355 2840170..2840556 + 387 WP_010429508.1 pyrimidine utilization protein C -
INS04_RS13360 2840564..2841364 + 801 WP_193804634.1 pyrimidine utilization protein D -
INS04_RS13365 2841374..2841964 + 591 WP_193804635.1 malonic semialdehyde reductase -
INS04_RS13370 2841974..2842468 + 495 WP_126328200.1 pyrimidine utilization flavin reductase protein F -
INS04_RS13375 2842490..2843812 + 1323 WP_193804636.1 pyrimidine utilization transport protein G -
INS04_RS13380 2843886..2844386 - 501 WP_172421424.1 GNAT family N-acetyltransferase Toxin
INS04_RS13385 2844414..2844683 - 270 WP_193804637.1 DUF1778 domain-containing protein Antitoxin
INS04_RS13390 2844745..2845662 - 918 WP_045354558.1 DMT family transporter -
INS04_RS13395 2845780..2845950 - 171 WP_023311077.1 general stress protein -
INS04_RS13400 2846342..2846938 + 597 WP_023311076.1 NAD(P)H:quinone oxidoreductase -
INS04_RS13405 2846959..2847186 + 228 WP_008499832.1 YccJ family protein -
INS04_RS13410 2847220..2848461 - 1242 WP_193804638.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
INS04_RS13415 2848614..2849057 + 444 WP_193804639.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18969.67 Da        Isoelectric Point: 7.9145

>T178248 WP_172421424.1 NZ_CP063441:c2844386-2843886 [Enterobacter asburiae]
MLSEGTDYDFEDFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMLPSKTQQRRIPYINV
PSVTLGRLAVDKTLQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKQGFIPLTAENSHSLFFPTKSIE
RLFEQE

Download         Length: 501 bp

>T178248 NZ_CP083886:3684685-3684963 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10190.66 Da        Isoelectric Point: 7.0169

>AT178248 WP_193804637.1 NZ_CP063441:c2844683-2844414 [Enterobacter asburiae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPGPNERLKR
AAKRLRNME

Download         Length: 270 bp

>AT178248 NZ_CP083886:3684422-3684682 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References