Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 746529..747186 Replicon chromosome
Accession NZ_CP063441
Organism Enterobacter asburiae strain SD4L

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag INS04_RS03555 Protein ID WP_021242050.1
Coordinates 746776..747186 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag INS04_RS03550 Protein ID WP_010435322.1
Coordinates 746529..746795 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INS04_RS03525 741712..743145 - 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -
INS04_RS03530 743262..743993 - 732 WP_193807223.1 MurR/RpiR family transcriptional regulator -
INS04_RS03535 744045..744356 + 312 WP_023309102.1 N(4)-acetylcytidine aminohydrolase -
INS04_RS03540 744522..745181 + 660 WP_023309101.1 hemolysin III family protein -
INS04_RS03545 745254..746234 - 981 WP_193805676.1 tRNA-modifying protein YgfZ -
INS04_RS03550 746529..746795 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
INS04_RS03555 746776..747186 + 411 WP_021242050.1 protein YgfX Toxin
INS04_RS03560 747193..747714 - 522 WP_008499710.1 flavodoxin FldB -
INS04_RS03565 747816..748712 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
INS04_RS03570 748741..749454 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
INS04_RS03575 749460..751193 + 1734 WP_045355605.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T178238 WP_021242050.1 NZ_CP063441:746776-747186 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T178238 NZ_CP083886:1072600-1072935 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT178238 WP_010435322.1 NZ_CP063441:746529-746795 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT178238 NZ_CP083886:1072352-1072600 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References