Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 256834..257430 Replicon chromosome
Accession NZ_CP063441
Organism Enterobacter asburiae strain SD4L

Toxin (Protein)


Gene name PumA Uniprot ID A0A4R0G5K0
Locus tag INS04_RS01175 Protein ID WP_039264167.1
Coordinates 257128..257430 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A2U3EU24
Locus tag INS04_RS01170 Protein ID WP_045355285.1
Coordinates 256834..257121 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INS04_RS01165 255206..256837 + 1632 WP_193805499.1 Na/Pi cotransporter family protein -
INS04_RS01170 256834..257121 - 288 WP_045355285.1 putative addiction module antidote protein Antitoxin
INS04_RS01175 257128..257430 - 303 WP_039264167.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
INS04_RS01180 257628..258500 + 873 WP_023309993.1 23S rRNA pseudouridine(2604) synthase RluF -
INS04_RS01185 258501..258773 - 273 WP_023309994.1 DUF3811 domain-containing protein -
INS04_RS01190 258824..259768 - 945 WP_193805500.1 ketopantoate/pantoate/pantothenate transporter PanS -
INS04_RS01195 259862..261211 - 1350 WP_047650899.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.17 Da        Isoelectric Point: 9.6038

>T178237 WP_039264167.1 NZ_CP063441:c257430-257128 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T178237 NZ_CP083886:937171-937578 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.55 Da        Isoelectric Point: 6.4596

>AT178237 WP_045355285.1 NZ_CP063441:c257121-256834 [Enterobacter asburiae]
MHKLTSYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp

>AT178237 NZ_CP083886:936924-937190 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G5K0

Antitoxin

Source ID Structure
AlphaFold DB A0A2U3EU24

References