178232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3148015..3149036 Replicon chromosome
Accession NZ_CP063440
Organism Proteus mirabilis strain Yak 2019

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag INT85_RS14610 Protein ID WP_017827532.1
Coordinates 3148467..3149036 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag INT85_RS14605 Protein ID WP_004245528.1
Coordinates 3148015..3148467 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT85_RS14585 3143802..3144332 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
INT85_RS14590 3144600..3145613 + 1014 WP_004250228.1 thiamine ABC transporter substrate binding subunit -
INT85_RS14595 3145613..3147193 + 1581 WP_004245526.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
INT85_RS14600 3147186..3147887 + 702 WP_049201584.1 thiamine ABC transporter ATP-binding protein ThiQ -
INT85_RS14605 3148015..3148467 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
INT85_RS14610 3148467..3149036 + 570 WP_017827532.1 PIN domain-containing protein Toxin
INT85_RS14615 3149152..3151506 + 2355 WP_049207719.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T178232 WP_017827532.1 NZ_CP063440:3148467-3149036 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

>T178232 NZ_CP083886:183051-183158 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT178232 WP_004245528.1 NZ_CP063440:3148015-3148467 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp

>AT178232 NZ_CP083886:c182994-182937 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References