Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1530354..1530999 Replicon chromosome
Accession NZ_CP063440
Organism Proteus mirabilis strain Yak 2019

Toxin (Protein)


Gene name hicA Uniprot ID B4ET86
Locus tag INT85_RS07145 Protein ID WP_004247035.1
Coordinates 1530814..1530999 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B4ET85
Locus tag INT85_RS07140 Protein ID WP_004247034.1
Coordinates 1530354..1530767 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT85_RS07110 1525899..1526057 - 159 WP_004247025.1 hypothetical protein -
INT85_RS07115 1526509..1526685 + 177 WP_185966348.1 hypothetical protein -
INT85_RS07120 1526862..1527608 - 747 WP_004247794.1 class I SAM-dependent methyltransferase -
INT85_RS07125 1528459..1529037 + 579 WP_004247796.1 alpha/beta hydrolase -
INT85_RS07130 1529150..1529443 - 294 Protein_1370 LysE family transporter -
INT85_RS07135 1529617..1530258 - 642 WP_065424673.1 response regulator -
INT85_RS07140 1530354..1530767 - 414 WP_004247034.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
INT85_RS07145 1530814..1530999 - 186 WP_004247035.1 type II toxin-antitoxin system HicA family toxin Toxin
INT85_RS07150 1531110..1531880 + 771 Protein_1374 DUF1073 domain-containing protein -
INT85_RS07155 1532174..1532326 + 153 WP_155289810.1 hypothetical protein -
INT85_RS07160 1532439..1532990 - 552 WP_049208654.1 PH domain-containing protein -
INT85_RS07165 1533094..1533369 - 276 WP_049208653.1 hypothetical protein -
INT85_RS07175 1533787..1535520 - 1734 WP_012367752.1 LPS biosynthesis-modulating metalloenzyme YejM -
INT85_RS07180 1535544..1535771 - 228 WP_004247042.1 YejL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ompA 1491810..1542993 51183


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7049.30 Da        Isoelectric Point: 10.9659

>T178231 WP_004247035.1 NZ_CP063440:c1530999-1530814 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Download         Length: 186 bp

>T178231 NZ_CP083886:182568-182675 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15251.98 Da        Isoelectric Point: 4.3830

>AT178231 WP_004247034.1 NZ_CP063440:c1530767-1530354 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Download         Length: 414 bp

>AT178231 NZ_CP083886:c182520-182454 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4ET86

Antitoxin

Source ID Structure
AlphaFold DB B4ET85

References