Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 748212..748872 Replicon chromosome
Accession NZ_CP063440
Organism Proteus mirabilis strain Yak 2019

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag INT85_RS03500 Protein ID WP_004245133.1
Coordinates 748212..748637 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E3RLN2
Locus tag INT85_RS03505 Protein ID WP_004245128.1
Coordinates 748630..748872 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT85_RS03470 743509..743958 + 450 WP_004245139.1 transcriptional regulator NrdR -
INT85_RS03475 744007..745164 + 1158 WP_004245138.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
INT85_RS03480 745377..745847 + 471 WP_004245137.1 6,7-dimethyl-8-ribityllumazine synthase -
INT85_RS03485 745876..746289 + 414 WP_004245136.1 transcription antitermination factor NusB -
INT85_RS03490 746383..747363 + 981 WP_004245135.1 thiamine-phosphate kinase -
INT85_RS03495 747449..747784 - 336 WP_004245134.1 phnA family protein -
INT85_RS03500 748212..748637 - 426 WP_004245133.1 type II toxin-antitoxin system VapC family toxin Toxin
INT85_RS03505 748630..748872 - 243 WP_004245128.1 hypothetical protein Antitoxin
INT85_RS03510 748988..749995 - 1008 WP_012367471.1 ribose operon transcriptional repressor RbsR -
INT85_RS03515 750000..750926 - 927 WP_004245126.1 ribokinase -
INT85_RS03520 751004..751894 - 891 WP_004245125.1 ribose ABC transporter substrate-binding protein RbsB -
INT85_RS03525 751934..752899 - 966 WP_004245124.1 ribose ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15924.18 Da        Isoelectric Point: 6.4879

>T178230 WP_004245133.1 NZ_CP063440:c748637-748212 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Download         Length: 426 bp

>T178230 NZ_CP083884:136409-136714 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9390.48 Da        Isoelectric Point: 4.6182

>AT178230 WP_004245128.1 NZ_CP063440:c748872-748630 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Download         Length: 243 bp

>AT178230 NZ_CP083884:136189-136407 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References