Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 11795..12396 Replicon chromosome
Accession NZ_CP063440
Organism Proteus mirabilis strain Yak 2019

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag INT85_RS00050 Protein ID WP_004246497.1
Coordinates 11795..12178 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag INT85_RS00055 Protein ID WP_004246496.1
Coordinates 12175..12396 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT85_RS00030 7728..8291 + 564 WP_012368640.1 methyltransferase -
INT85_RS00035 8567..9466 + 900 WP_124725698.1 N-acetylmuramic acid 6-phosphate etherase -
INT85_RS00040 9823..11061 - 1239 WP_126402683.1 HipA domain-containing protein -
INT85_RS00045 11074..11388 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
INT85_RS00050 11795..12178 - 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
INT85_RS00055 12175..12396 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
INT85_RS00060 13044..13745 - 702 WP_046127256.1 hypothetical protein -
INT85_RS00065 13746..14936 - 1191 WP_046127255.1 nucleotidyltransferase -
INT85_RS00070 14929..16083 - 1155 WP_046127254.1 SAVED domain-containing protein -
INT85_RS00075 16093..16461 - 369 WP_046127253.1 metal-dependent hydrolase -
INT85_RS00080 16765..17316 - 552 WP_046127252.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T178229 WP_004246497.1 NZ_CP063440:c12178-11795 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T178229 NZ_CP083884:c133578-133162 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGATGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTGACGAATAATACAAGAGAATTTGAGCGGGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT178229 WP_004246496.1 NZ_CP063440:c12396-12175 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT178229 NZ_CP083884:c133805-133575 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGCTCATTCCTGGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References