Detailed information of TA system TA178226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2666733..2667655
• Replicon: chromosome
• Accession: NZ_CP063427
• Organism: Citrobacter sp. BDA59-3

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IP582_RS12510
• Protein ID: WP_193796150.1
• Coordinates: 2666733..2667209 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IP582_RS12515
• Protein ID: WP_193796151.1
• Coordinates: 2667209..2667655 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IP582_RS12490	2661989..2663644	+	1656	WP_193796147.1	iron ABC transporter permease	-
IP582_RS12495	2663720..2664562	+	843	WP_132439285.1	N-hydroxyarylamine O-acetyltransferase	-
IP582_RS12500	2664544..2665134	-	591	WP_193796148.1	TetR family transcriptional regulator	-
IP582_RS12505	2665247..2666749	+	1503	WP_193796149.1	MFS transporter	-
IP582_RS12510	2666733..2667209	-	477	WP_193796150.1	RES family NAD+ phosphorylase	Toxin
IP582_RS12515	2667209..2667655	-	447	WP_193796151.1	DUF2384 domain-containing protein	Antitoxin
IP582_RS12520	2667721..2668602	-	882	WP_193796152.1	aromatic amino acid DMT transporter YddG	-
IP582_RS12525	2668935..2671982	+	3048	WP_193796153.1	formate dehydrogenase-N subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-150)

Antitoxin

• Antitoxin Xre (17-147)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17817.39 Da
• Isoelectric Point: 5.2290

>T178226 WP_193796150.1 NZ_CP063427:c2667209-2666733 [Citrobacter sp. BDA59-3]
METVTFWRLVKERYALTAFDGYGARTFGGRWNSPGHECVYLGESKALCVLETLVHLEIEDIAQGYCFLTLDVPRNLIATL
DLTALPEDWKSDPPPVYTQHIGDEWLASKQNGLVLRVPSTITGEWNALFNPEHPQAAKVLKSVKSEPFMLDPRLSRPC

Nucleotide

• Length: 477 bp

>T178226 NZ_CP083884:c32688-32290 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 15618.00 Da
• Isoelectric Point: 9.6238

>AT178226 WP_193796151.1 NZ_CP063427:c2667655-2667209 [Citrobacter sp. BDA59-3]
MQLYTPGVRAIPHDLLSILGLPATAIAAHDSINAGLSAGVLRDIAGAVSLDEITLCRMAGIDRNTYSRRLNSAEKRFSPE
QSARVYTLARVISAARELFEGDSGRMATWLNKPAKGLGGKKPAELLSTPAGAEAVLTLIGRLEHGVIG

Nucleotide

• Length: 447 bp

>AT178226 NZ_CP083884:c32915-32688 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA