Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 32786..33429 Replicon plasmid pBDA62-3
Accession NZ_CP063426
Organism Kosakonia pseudosacchari strain BDA62-3

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag IP581_RS23535 Protein ID WP_193822796.1
Coordinates 33013..33429 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag IP581_RS23530 Protein ID WP_193822795.1
Coordinates 32786..33016 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP581_RS23495 28190..28417 + 228 WP_193822791.1 hypothetical protein -
IP581_RS23500 28568..28780 - 213 WP_193822792.1 hypothetical protein -
IP581_RS23505 29377..29778 + 402 WP_193822793.1 hypothetical protein -
IP581_RS23510 29779..30067 + 289 Protein_38 hypothetical protein -
IP581_RS23515 30455..31243 - 789 WP_144136437.1 site-specific integrase -
IP581_RS23520 31292..31789 - 498 WP_144136436.1 site-2 protease family protein -
IP581_RS23525 31907..32215 - 309 WP_193822794.1 hypothetical protein -
IP581_RS23530 32786..33016 + 231 WP_193822795.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IP581_RS23535 33013..33429 + 417 WP_193822796.1 type II toxin-antitoxin system VapC family toxin Toxin
IP581_RS23540 33459..34202 + 744 WP_193822797.1 hypothetical protein -
IP581_RS23545 34410..35336 + 927 WP_193822798.1 hypothetical protein -
IP581_RS23550 35836..36864 + 1029 WP_193822799.1 Abi family protein -
IP581_RS23555 36954..37427 + 474 WP_193822800.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93051 93051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15055.44 Da        Isoelectric Point: 7.8603

>T178215 WP_193822796.1 NZ_CP063426:33013-33429 [Kosakonia pseudosacchari]
VNRTYMLDTNICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVLLVDAFCARLDAVLPWDRA
AVDATTDIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

>T178215 NZ_CP083880:2618973-2619080 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8752.84 Da        Isoelectric Point: 4.4692

>AT178215 WP_193822795.1 NZ_CP063426:32786-33016 [Kosakonia pseudosacchari]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFTQLEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT178215 NZ_CP083880:c2618926-2618860 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References