Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4801870..4802516 Replicon chromosome
Accession NZ_CP063425
Organism Kosakonia pseudosacchari strain BDA62-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IP581_RS22785 Protein ID WP_193821437.1
Coordinates 4801870..4802274 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IP581_RS22790 Protein ID WP_162494953.1
Coordinates 4802274..4802516 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP581_RS22760 4797133..4797441 + 309 WP_193821433.1 SymE family type I addiction module toxin -
IP581_RS22765 4797716..4797997 + 282 WP_193821434.1 hypothetical protein -
IP581_RS22770 4798046..4799149 - 1104 WP_097399796.1 alkene reductase -
IP581_RS22775 4799264..4799938 - 675 WP_193821435.1 LuxR family transcriptional regulator -
IP581_RS22780 4800803..4801873 + 1071 WP_193821436.1 AbrB family transcriptional regulator -
IP581_RS22785 4801870..4802274 - 405 WP_193821437.1 tRNA(fMet)-specific endonuclease VapC Toxin
IP581_RS22790 4802274..4802516 - 243 WP_162494953.1 antitoxin Antitoxin
IP581_RS22795 4802627..4803508 - 882 WP_193821438.1 dihydrodipicolinate synthase family protein -
IP581_RS22800 4803519..4804211 - 693 WP_097399790.1 B3/4 domain-containing protein -
IP581_RS22805 4804257..4804859 + 603 WP_193821439.1 XRE family transcriptional regulator -
IP581_RS22810 4804970..4806133 + 1164 WP_193821440.1 multidrug effflux MFS transporter -
IP581_RS22815 4806356..4806751 + 396 WP_097399787.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(11-58)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14781.15 Da        Isoelectric Point: 8.5190

>T178214 WP_193821437.1 NZ_CP063425:c4802274-4801870 [Kosakonia pseudosacchari]
MLKFMLDTNICIFTIKNKPEIVRQAFNQHSGQMCISSVTLMELIYGAEKSAIPDKNLRVVEGFTARLEVLPYGVDAAVHT
GQLRAELARAGTPVGPYDAMIGAHARSLGLVLVSNNTREFARIPGLRLQDWTSH

Download         Length: 405 bp

>T178214 NZ_CP083880:2618438-2618545 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.06 Da        Isoelectric Point: 4.5098

>AT178214 WP_162494953.1 NZ_CP063425:c4802516-4802274 [Kosakonia pseudosacchari]
MEARVEKTTVFKSNRSQAVRLPKAVALPEDVKHVDIIAVGRTRIITPSGEAWDSWFDGESASPDFMAAREQPEEQDREDF

Download         Length: 243 bp

>AT178214 NZ_CP083880:c2618391-2618325 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References