Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 541297..541813 Replicon chromosome
Accession NZ_CP063425
Organism Kosakonia pseudosacchari strain BDA62-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IP581_RS02505 Protein ID WP_086872939.1
Coordinates 541529..541813 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1G4YUC9
Locus tag IP581_RS02500 Protein ID WP_017459099.1
Coordinates 541297..541539 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP581_RS02485 537401..539311 + 1911 WP_193821674.1 BglG family transcription antiterminator -
IP581_RS02490 539346..540179 - 834 WP_193821675.1 oxidoreductase -
IP581_RS02495 540284..541204 + 921 WP_193821676.1 AraC family transcriptional regulator -
IP581_RS02500 541297..541539 + 243 WP_017459099.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IP581_RS02505 541529..541813 + 285 WP_086872939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IP581_RS02510 541819..542283 - 465 WP_086872938.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IP581_RS02515 542545..544680 - 2136 WP_086872937.1 anaerobic ribonucleoside-triphosphate reductase -
IP581_RS02520 545065..546720 - 1656 WP_193821677.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11066.02 Da        Isoelectric Point: 10.6325

>T178200 WP_086872939.1 NZ_CP063425:541529-541813 [Kosakonia pseudosacchari]
MNYELVFDPRAYKEWKKLGATVKTQFKKKLAEVLVQPRIEKARLHQFPDCYKIKLRTSGYRLVYQVRDNVVTVFVVSIGK
REKAAAYQDASKRL

Download         Length: 285 bp

>T178200 NZ_CP083878:66939-67088 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9176.65 Da        Isoelectric Point: 4.8409

>AT178200 WP_017459099.1 NZ_CP063425:541297-541539 [Kosakonia pseudosacchari]
MATLNVRLDDKLKEEAWRVLEKLNITPTEAVRLLFQYVAENGRMPIKTVTVSEDESALLEIVRERLANPQKGIKVNLDEL

Download         Length: 243 bp

>AT178200 NZ_CP083878:c66895-66834 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1G4YUC9

References