Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | toxTA/Tad-couple_hipB |
Location | 211158..211803 | Replicon | chromosome |
Accession | NZ_CP063424 | ||
Organism | Actinobacillus pleuropneumoniae strain APP5 |
Toxin (Protein)
Gene name | toxT | Uniprot ID | B0BQU7 |
Locus tag | IOD66_RS01055 | Protein ID | WP_005619674.1 |
Coordinates | 211158..211529 (+) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | toxA | Uniprot ID | - |
Locus tag | IOD66_RS01060 | Protein ID | WP_005598477.1 |
Coordinates | 211510..211803 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IOD66_RS01040 (IOD66_01050) | 207688..208542 | + | 855 | WP_009874917.1 | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | - |
IOD66_RS01045 (IOD66_01055) | 208586..209155 | - | 570 | WP_005601959.1 | elongation factor P hydroxylase | - |
IOD66_RS01050 (IOD66_01060) | 209213..210964 | - | 1752 | WP_005601957.1 | protein-disulfide reductase DsbD | - |
IOD66_RS01055 (IOD66_01065) | 211158..211529 | + | 372 | WP_005619674.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IOD66_RS01060 (IOD66_01070) | 211510..211803 | + | 294 | WP_005598477.1 | helix-turn-helix domain-containing protein | Antitoxin |
IOD66_RS01065 (IOD66_01075) | 211881..212843 | - | 963 | WP_005619672.1 | calcium/sodium antiporter | - |
IOD66_RS01070 (IOD66_01080) | 212916..213413 | + | 498 | WP_005601953.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
IOD66_RS01075 (IOD66_01085) | 213638..214372 | + | 735 | WP_005612838.1 | arginine ABC transporter ATP-binding protein ArtP | - |
IOD66_RS01080 (IOD66_01090) | 214392..215111 | + | 720 | WP_011848574.1 | transporter substrate-binding domain-containing protein | - |
IOD66_RS01085 (IOD66_01095) | 215117..215788 | + | 672 | WP_247797613.1 | arginine ABC transporter permease ArtQ | - |
IOD66_RS01090 (IOD66_01100) | 215788..216471 | + | 684 | WP_005605188.1 | arginine ABC transporter permease ArtM | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 15066.57 Da Isoelectric Point: 10.4054
>T178193 WP_005619674.1 NZ_CP063424:211158-211529 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF
Download Length: 372 bp
>T178193 NZ_CP083877:2618910-2619017 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10935.81 Da Isoelectric Point: 10.3120
>AT178193 WP_005598477.1 NZ_CP063424:211510-211803 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR
Download Length: 294 bp
>AT178193 NZ_CP083877:c2618863-2618797 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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