Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 211158..211803 Replicon chromosome
Accession NZ_CP063424
Organism Actinobacillus pleuropneumoniae strain APP5

Toxin (Protein)


Gene name toxT Uniprot ID B0BQU7
Locus tag IOD66_RS01055 Protein ID WP_005619674.1
Coordinates 211158..211529 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag IOD66_RS01060 Protein ID WP_005598477.1
Coordinates 211510..211803 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD66_RS01040 (IOD66_01050) 207688..208542 + 855 WP_009874917.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
IOD66_RS01045 (IOD66_01055) 208586..209155 - 570 WP_005601959.1 elongation factor P hydroxylase -
IOD66_RS01050 (IOD66_01060) 209213..210964 - 1752 WP_005601957.1 protein-disulfide reductase DsbD -
IOD66_RS01055 (IOD66_01065) 211158..211529 + 372 WP_005619674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD66_RS01060 (IOD66_01070) 211510..211803 + 294 WP_005598477.1 helix-turn-helix domain-containing protein Antitoxin
IOD66_RS01065 (IOD66_01075) 211881..212843 - 963 WP_005619672.1 calcium/sodium antiporter -
IOD66_RS01070 (IOD66_01080) 212916..213413 + 498 WP_005601953.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
IOD66_RS01075 (IOD66_01085) 213638..214372 + 735 WP_005612838.1 arginine ABC transporter ATP-binding protein ArtP -
IOD66_RS01080 (IOD66_01090) 214392..215111 + 720 WP_011848574.1 transporter substrate-binding domain-containing protein -
IOD66_RS01085 (IOD66_01095) 215117..215788 + 672 WP_247797613.1 arginine ABC transporter permease ArtQ -
IOD66_RS01090 (IOD66_01100) 215788..216471 + 684 WP_005605188.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(32-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15066.57 Da        Isoelectric Point: 10.4054

>T178193 WP_005619674.1 NZ_CP063424:211158-211529 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

>T178193 NZ_CP083877:2618910-2619017 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10935.81 Da        Isoelectric Point: 10.3120

>AT178193 WP_005598477.1 NZ_CP063424:211510-211803 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Download         Length: 294 bp

>AT178193 NZ_CP083877:c2618863-2618797 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3N206

Antitoxin

Source ID Structure

References